The Kemaladewi Lab has multiple positions for postdoctoral fellows (experienced candidates can be employed at research scientist level) to study the impact of genetic diversity in muscular dystrophy & response to therapies. This project is supported by a highly competitive NIH Director’s New Innovator Award, part of the High-Risk, High-Reward Program, to Dr. Kemaladewi and will be further strengthened with an anticipated NIH R01 grant to the Kemaladewi Lab.
The problem: Differences in our individual genomes give rise to most of human diversity, including the severity of disease presentations and responses to therapies. The development of CRISPR-based genome editing has sparked intense interest in the use of this technology for therapeutic interventions, including muscular dystrophies. Yet, the component of genetic diversity has been largely ignored in many preclinical studies.
The approach: You will develop and use genetically diverse animal models of human diseases to identify novel genetic modifier factors. The first focus will be on congenital-onset muscular dystrophy and the evaluation of disease modifiers in neuromuscular, respiratory, and neurological phenotypes. Some efforts will also go towards an evaluation of the efficacy and safety of a variety of innovative therapeutic genome editing in genetically diverse patient samples, befitting the truly translational nature of the project and the laboratory.
The team: You will be a member of a young, collaborative, energetic, and international research group with a strong commitment to improve the lives of individuals affected by pediatric rare diseases, including neuromuscular and neurological disorders. The laboratory is located in the Rangos Research Building of the UPMC Children’s Hospital of Pittsburgh. In-house core facilities provide state-of-the-art technologies, including animal and cellular imaging, AAV production, flow cytometry, metabolic and genomic analyses. Our lab is equipped with dedicated instruments to assess neuromuscular functions in small animals. You will have access to full educational and professional development opportunities offered by the University of Pittsburgh School of Medicine.
Interested candidates should submit a cover letter describing career aspiration and potential fit to the laboratory/project, a CV, and contact detail of three references to email@example.com. Request for an informal discussion/inquiry is welcome.
Tagged as: Life Sciences
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