The Weaver laboratory at Vanderbilt University is looking for motivated and independent postdoctoral fellows to make fundamental discoveries in the area of tumor and host cell extracellular vesicles (EVs), including exosomes. Exosomes and other extracellular vesicles carry autocrine and paracrine factors that promote cancer aggressiveness. However, how they do so is poorly understood. The Weaver laboratory is actively investigating the underlying cellular and molecular mechanisms that control tumor cell-EV interactions. The major areas of interest are: 1) how exosomes control both tumor and normal cell biology, especially as it relates to cell adhesion, migration, invasion and metastasis; 2) how RNA cargoes of extracellular vesicles are selected and packaged for secretion; 3) developing tools to track secretion, function and delivery of EV cargos; and 4) identifying molecular EV cargoes that drive recipient cell behaviors and cancer aggressiveness. Our laboratory has a strong background in EV biology, tumor microenvironment, cell adhesion, cytoskeleton, membrane trafficking, live cell imaging, mouse tumor models, and 3D culture. We also utilize bioinformatics and computational approaches. We have specific projects in breast cancer, head and neck squamous carcinoma, colon cancer, and lung cancer, but are generally interested in fundamental mechanisms that cross cancer types, as well as extend to normal cells and tissues.
Recent publications of interest include:
1. Jimenez, L, Yu, H, McKenzie, AJ, Franklin, JL, Patton, JG, Liu, Q, and AM Weaver, “Quantitative proteomic analysis of small and large extracellular vesicles (EVs) reveals enrichment of adhesion proteins in small EVs”, J. Proteome Res., 18:947–959, 2019. PMCID: PMC6411421
2. Sato, S, Vasaikar, S, Eskaros, A, Kim, Y, Lewis, JL, Zhang, B, Zijlstra, A, and AM Weaver, “EPHB2 carried on small extracellular vesicles induces tumor angiogenesis via activation of ephrin reverse signaling”, JCI Insight, 4(23):e132447, 2019. https://doi.org/10.1172/jci.insight.132447. PMCID: PMC6962030
3. Sung, BH, von Lersner, A, Guerrero, J, Inman, D, Pelletier, R, Zijlstra, A, Ponik, S.M., and AM Weaver, “pHluo_M153R-CD63, a bright, versatile live cell reporter of exosome secretion and uptake, reveals pathfinding behavior of migrating cells.”, Nature Communications, 11:2092, 2020 PMCID: PMC7190671
4. Barman, B, Ping, J, Krystofiak, E, Allen, R, Prasad, N, Vickers, K, Patton, JG, Liu, Q, Weaver, AM “Biogenesis of RNA-containing extracellular vesicles at endoplasmic reticulum membrane contact sites.” Submitted, 2020 and https://www.biorxiv.org/content/10.1101/2020.12.04.412379v1
For more information, please see our website: https://my.vanderbilt.edu/alissaweaver/
Also, please see the website for the Vanderbilt Program for Extracellular Vesicle Research that Dr. Weaver directs:https://medschool.vanderbilt.edu/evresearch/
Candidates must be within 2 years of their terminal degree with a strong publication record. The ideal candidate will be highly motivated to develop their own research program and possess a Ph.D. degree with a strong background in biochemistry, molecular, and cellular biology, along with some knowledge of the cancer field. Good oral and written communication skills are required. Salary will be commensurate with experience and paid at NIH scale. Vanderbilt University is located in Nashville, Tennessee, a vibrant and affordable city with a strong artistic bent.
To apply, please contact Dr. Alissa Weaver at Alissa.email@example.com with your CV and a short statement about why you are interested in postdoctoral training in the Weaver laboratory.
Tagged as: Life Sciences
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