The Kulkarni lab, is a NIH-funded laboratory in the Division of Pulmonary and Critical Care Medicine at Washington University. We are seeking a staff scientist and/or a research technician with prior experience to investigate how innate immune responses, such as the complement system, modulate the severity of lung injury. The overarching goal of our research program is to determine how epithelial cell-derived proteins can be harnessed to mitigate the risk of acute lung injury in various settings, to ultimately reduce the burden of end-stage lung disease. We have active projects investigating lung injury due to bacterial infections (such as Pseudomonas aeruginosa and Staphylococcus aureus), and the short- and long-term consequences of ischemia-reperfusion injury occurring in the context of lung transplantation. We utilize state-of-the-art technical modalities including flow cytometry, ELISA, protein and DNA-based molecular biology, biochemistry, cell/tissue culture, fluorescence and confocal microscopy, and DNA/RNA sequencing. The staff scientist will be responsible for both conducting experiments, including animal experiments, and developing and executing the plans in the laboratory, in partnership with the principal investigator.
For additional details, visit: https://sites.wustl.edu/kulkarnilab
A major focus of our work involves distinguishing the role of locally-derived complement proteins in the lung from those present in the blood, and how they modulate the development of pneumonia and acute lung injury. We use multiple in vitro and in vivo approaches to dissect the mechanism by which these proteins contribute to cellular survival. We have a robust collaboration with our Airway Epithelial Cell Core, wherein we work with primary tracheobronchial cells, and the Department of Surgery, with whom we investigate models of experimental lung transplantation. Additionally, we draw upon a robust biorepository of lung tissue, bronchoalveolar lavage fluid and DNA from lung transplant recipients to guide and validate our research.
Potentially interested candidates should send CV, letter of intent/statement of purpose, and at least two references to email@example.com.
Tagged as: Life Sciences
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