The group of Ashley Laughney at Weill Cornell Medicine in New York City, is seeking innovative and highly motivated computational postdoctoral researchers to contribute to our systems biology study of metastasis. The lab combines high-throughput single cell transcriptional profiling with development of new computational tools, synthetic biology approaches and cancer models, to understand the context-dependent interplay between inflammation and stemness during the evolution of metastasis.
The invasion-metastasis cascade is a dynamic, multistep process the requires adaptation to a less hospitable microenvironment, immune evasion, and progression from the micro- to macro-metastatic stage, resulting in generation of a secondary tumor. A key driver of this transition is chronic inflammatory signaling emanating from tumor cells themselves, which can be triggered by the presence of nucleic acids in the cytoplasm. Chronic inflammation engages pathways central to a wound-healing response, which has profound consequences on tumor cell migration (Nature 553, 467-472), lineage plasticity, and tumor-immune interactions (Nature Medicine 26, 259-269). We are especially interested in understanding the impact of chronic inflammatory signaling on bi- directional crosstalk between cancer cells and their microenvironment, and how metastases have adapted resistance to this chronic inflammatory signaling without triggering an anti-tumor immune response.
We are a highly inter-disciplinary team recruiting from diverse backgrounds, including both theory and experiment. We are currently seeking candidates with backgrounds in Computational Biology, Mathematics, Computer Science, Statistics or related fields interested in developing robust and innovative tools for constructing cell type-specific gene regulatory networks and higher-order epistasis models from single cell data coupled with combinatorial genetic perturbations. Experience with machine learning, combinatorial optimization, or statistical methods and modeling is desired.
Each position is fully funded through a collaborative R01 with the Samuel Bakhoum Lab and builds upon the exceptional resources and community of scientists at three of New York City’s premier research institutions: Weill Cornell Medical College, The Rockefeller University and Memorial Sloan Kettering Cancer Center. We offer competitive benefits and access to subsidized Cornell housing in Manhattan and Roosevelt Island.
Interested applicants should email the following items as a single PDF to LaughneyLabPositions@gmail.com: (1) cover letter indicating research interests and reasons for applying, (2) your curriculum vitae, (3) names and contact information for three references and (4) up to two reprints.
Tagged as: Computer Science, Engineering, Mathematics, Physics
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