Are you interested in molecular/cellular neurobiology, advanced microscopy and protein engineering techniques?
If so, and if you have already completed (or are about to complete) an MSc degree (or equivalent) in molecular biology, neuroscience, biochemistry or related fields, please consider joining our laboratory at the Werner Reichardt Centre for Integrative Neuroscience (CIN), University of Tübingen, Germany.
Our laboratory works in the field of axonal biology and develops new genetic code expansion-based techniques for bioorthogonal protein labeling. We previously described a novel form of axonal injury in a mouse model of a common neuroinflammatory disease, multiple sclerosis (Nikić et al, Nat Medicine 2011). Our current work involves a variety of cellular, molecular, and microscopy techniques, including live-cell, intravital, confocal and super-resolution imaging. For example, to elucidate molecular mechanisms underlying axonal stability and breakdown, we use super-resolution microscopy and genetic code expansion-based protein-engineering techniques to attach fluorescent dyes for microscopy or tags for cell-specific proteomics (Nikić-Spiegel, ChemBioChem 2020; Nikić et al, Angew Chem 2016; Nikić et al, Nat Protocols 2015; Nikić et al, Angew Chem 2014).
If you are interested, please send your full application (in English) as a single pdf file – including a cover letter, CV, academic transcripts, and contact details of 2-3 referees by email to: email@example.com. The CIN is an equal opportunity employer and the position will remain open until filled.
More information about our work can be found here:
Nikić-Spiegel I, “Expanding the genetic code for neuronal studies”, Chembiochem. 2020 PMID: 32531101
Nikić et al, “Debugging Eukaryotic Genetic Code Expansion for Site-Specific Click-PAINT Super-Resolution Microscopy”, Angewandte Chemie 2016, PMID: 27804198
Nikić et al, “Minimal Tags for Rapid Dual-Color Live-Cell Labeling and Super-Resolution Microscopy”, Angewandte Chemie 2014, PMID: 24474648
Nikić et al, “A Reversible Form of Axon Damage in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis”, Nature Medicine 2011, PMID: 21441916
Tagged as: Life Sciences
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