We are seeking a postdoctoral fellow to join the laboratory of Dr. Grace Chen at Yale University in the Department of Immunobiology. The Chen lab aims to generate novel therapies to treat cancer and autoimmune diseases based on our basic science understanding about RNA function and regulation. We investigate the mechanisms and regulation of circular RNAs (circRNAs), a newly identified class of ubiquitous RNAs in essentially all eukaryotes and some viruses. Thus far, circRNAs have been found to function as miRNA sponges, regulate transcription, and act as templates for translation. However, there are still many unanswered questions: What other functions do circRNAs possess? How are circRNAs degraded? What are their interacting proteins? Specifically, we aim to understand how different layers of regulation including RNA modifications and cellular localization affect RNA function to enable new insights into both normal function and how dysregulation leads to disease. The Chen Laboratory applies molecular, cellular, and chemical biology techniques coupled with next-generation sequencing to address these questions. For more information, visit gracechenlab.org. Interested applicants please send a brief statement of interest and curriculum vitae with contact information for three references to the PI Dr. Grace Chen at firstname.lastname@example.org.
Tagged as: Chemistry, Life Sciences
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