The Noonan Lab in the Department of Genetics, Yale School of Medicine, is recruiting postdoctoral fellows to join a major collaborative project to study the evolution of the human brain. We are supported by a generous grant from the Nomis Foundation. The goal of the project is to understand how gene regulatory innovations contributed to the evolution of novel human brain features. We are pursuing three major approaches. First, we are using genome editing to introduce human-specific genetic changes into the mouse genome. These “humanized” mouse models will reveal how human-specific genomic features alter brain development, circuitry and function in a living system we can comprehensively study. Second, we are using induced pluripotent stem cells from humans, chimpanzees and other primates to generate and characterize “mini-brains,” three-dimensional cellular structures that mimic the early aspects of brain development. This approach will help us learn how human and chimpanzee brains differ during development and will enable us to identify the genetic changes underlying these divergent developmental outcomes. Third, we are using massively parallel screens, including CRISPR perturbation and massively parallel reporter assays, to map human-specific gene regulatory functions in the genome and understand their contribution to neurodevelopment.
We welcome applications from candidates with experience in comparative and functional genomics, genome evolution, genetic and experimental studies of neurodevelopment in mammalian systems, the application of genome editing technologies in genome-wide screens, and other areas of neuroscience that may contribute to the project. Applicants must hold a PhD at the time of appointment.
Please send your CV, contact information for 2-3 references, and a cover letter explaining your interest in the position to Jim Noonan at firstname.lastname@example.org. Please include ‘Nomis Project Postdoc Application’ in the subject line. We strongly encourage investigators from diverse backgrounds to apply.
Since opening in 2007, the Noonan Lab has made multiple contributions to our understanding of the nature, location and biology of uniquely human gene regulatory functions and their role in the evolution of human traits. You can find a summary of our research here and a list of our publications here. We are strongly committed to providing a vibrant and supportive mentoring environment for trainees at all career stages and from all backgrounds. Graduate students and postdocs from our lab have gone on to tenure-track faculty positions (e.g., Columbia, UCONN Health, Yale) and positions in industry.
Tagged as: Life Sciences
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