Associate Director/ Principal Scientist, Computational Chemistry, Research Full-time

Job Title

Better Health for People, Brighter Future for the World

Takeda is a global values-based, R&D-driven biopharmaceutical leader. We are guided by our values of Takeda-ism, which has been passed down since the company's founding. Takeda-ism incorporates Integrity, Fairness, Honesty, and Perseverance, with Integrity at the core. They are brought to life through actions based on Patient-Trust-Reputation-Business, in this order.

We aim to create a diverse and inclusive organization where people can thrive, grow and realize their own potential while enabling our purpose. We continue to innovate and drive changes that will transform the lives of patients. We're looking for like-minded professionals to join us.

Objectives/Purpose

• Work as part of a multi-disciplinary team of computational chemists, medicinal chemists, structural biologists, data scientists, pharmacologists and biologists and provide computational expertise to advance drug discovery projects.
• Contribute to drug discovery efforts across various modalities including small molecules, PROTACs, RNA inhibitors, peptides, and more.
• Implement and execute innovative computational methodologies and tools such as AI, free energy, and cheminformatics approaches to support drug discovery efforts.

Accountabilities

• Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.
• Build and develop a strong team of Computational Chemists to high productivity levels.
• Identify, develop, validate, and implement innovative computational approaches that enhance research productivity and success.
• Provide key technical knowledge and input to project teams to drive decision-making in drug discovery projects.

Dimensions and Aspects

Technical/Functional (Line) Expertise

• Expertise in a variety of computational tools and methodology including generative chemistry, large-scale virtual screening, molecular dynamics, homology modeling, quantum mechanics, pharmacophore elucidation, data mining, machine learning, cheminformatics and more.
• Significant industry experiences contributing as a computational chemist on drug discovery projects against several therapeutic areas and a variety of drug discovery targets (GPCRs, Kinases, Ion channel etc.).
• Strong impact in progressing discovery projects from hits to clinical leads
• Familiarity with organic and synthetic chemistry concepts.
• Provide project teams with computational strategies to inform, influence, and prioritize designs for potency/selectivity and improve ADME/Tox endpoints.
• Ability to effectively integrate emerging generative chemistry methods and other modern machine learning and artificial intelligence (AI) applications in small molecule drug discovery.
• Proficiency with state-of-the-art Computational Chemistry software.

Leadership

• Identifies, plans and executes novel scientific projects and lead platform initiatives.
• Enables information sharing, helps groups to understand each other and brings them together.
• Accurately identifies strengths and development needs in others and invests time to help enhance their skills.

Interaction

• Conducts scientific presentations to internal and external audiences
• Collaborate with cross functional scientists and across geographic areas.

Education, Behavioral Competencies and Skills:

• PhD degree in Chemistry or equivalent
• Expected: Ideally, 7+ years of experience in industry (pharma/biotech) drug discovery experience.

Takeda Compensation and Benefits Summary:

• Allowances: Commutation, Housing, Overtime Work etc.
• Salary Increase: Annually, Bonus Payment: Twice a year
• Working Hours: Headquarters (Osaka/ Tokyo) 9:00-17:30, Production Sites (Osaka/ Yamaguchi) 8:00-16:45, (Narita) 8:30-17:15, Research Site (Kanagawa) 9:00-17:45
• Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)
• Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave.
• Flexible Work Styles: Flextime, Telework
• Benefits: Social Insurance, Retirement and Corporate Pension, Employee Stock Ownership Program, etc.

Important Notice concerning working conditions:

• It is possible the job scope may change at the company's discretion.
• It is possible the department and workplace may change at the company's discretion.

Locations

Fujisawa, Japan

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time