Associate Research Scientist: LC/MS, HPLC Full-time NEW

Job Title

At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life – enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on – now and in the future.

Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission – to enable our customers to make the world healthier, safer, and cleaner.

Within our Analytical Services team, we have a functional service provider solution, which is a unique partnership that allows our customers to leverage the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits.

The primary purpose of this position is to contribute to developing, validating, and implementing bioanalytical LC-MS/MS to quantify drugs and related compounds in biological samples to support drug development and regulatory filings.

• Perform method development, method validation, and sample analysis using LC-MS/MS to support non-clinical and clinical studies and embrace the power of new technologies in a non-GLP environment.

• Independently troubleshoot LC-MS/MS assays when problems arise.

• Assist with method development for ligand binding assays for analysis of clinical and non-clinical pharmacokinetic or toxicokinetic samples

• Keep accurate and timely documentation of notebooks and study records per departmental guidelines and SOPs.

• Follow applicable company and departmental SOPs, safety, health authority guidance, GLPs, and other departmental guidelines.

• Keep current with required company and department trainings.

• Prepare or contributes to study reports following the departmental policies and procedures.

• Coordinate with necessary service engineers for instrument maintenance scheduling and handle service documentation for regulated equipment.

• Contribute to preparing and making scientific presentations at internal and external meetings.

• Maintain lab inventories and order lab supplies to ensure continuity of bioanalytical activities.

Possess a solid understanding of basic analytical concepts (concentration units, pH, calibration curves, QCs, compliance, etc.)

Good basic analytical lab operational skills (pipettors, balances, digital literacy, etc).

Excellent observation powers. Ability to work in a methodical and organized fashion. Ability to read and follow method or research protocols. Ability to write in a concise fashion in order to record all pertinent data in research book.

Experience in biological sample handling

Experience in automated liquid handlers (Hamilton) for sample aliquoting and extraction in 96-well format.

Proven technical expertise in extraction techniques (PPT, LLE, SPE, etc.), execution and troubleshooting of LC-MS/MS methods on at least one Sciex Triple Quad MS platform instrument

Strong HPLC operational skills; basic theoretical understanding of HPLC – chromatographic modes (reversed phase, normal phase, etc.); column types, resolution parameters (void volume, retention factor, etc.), effect of column dimensions and flow rate on resolution, and gradient vs. isocratic elution

Understanding of SRM optimization: effect of mobile phase; in-source CID; mass resolution. Some experience in LIMS (e.g. Watson) for quantitation, data handling and archival

Knowledge of GLP, 21 CFR Part 11, Regulatory Bioanalytical Guidance and general laboratory practices

Possess excellent communication and organizational skills in a cross-functional environment.

Bachelor's degree in relevant life sciences program field AND 6-8 years of experience that provides the knowledge, skills, and abilities to perform the job.

In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.

Able to work upright and stationary and/or standing for typical working hours.

Able to lift and move objects up to 25 pounds

Able to work in non-traditional work environments.

Able to use and learn standard office equipment and technology with proficiency.

May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.

Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.

Our Mission is to enable our customers to make the world healthier, cleaner and safer. Watch as our colleagues explain 5 reasons to work with us. As one team of 100,000+ colleagues, we share a common set of values – Integrity, Intensity, Innovation and Involvement – working together to accelerate research, solve complex scientific challenges, drive technological innovation and support patients in need. #StartYourStory with PPD, part of Thermo Fisher Scientific, where diverse experiences, backgrounds and perspectives are valued.