Associate Scientist I, CGM Discovery Full-time

Associate Scientist I

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Purpose: This role will focus on CAR screening and lead selection (CSLS) to support the development of CAR-T cell therapies.

This position offers an exciting opportunity to contribute to the field of CAR-T cell therapy and work alongside a team of passionate scientists advancing cutting-edge treatments targeting hematological and solid tumors.

Key Responsibilities:

• Assist in the culture and expansion of primary T cells, as well as the generation of CAR-T cells via viral transduction techniques
• Support the development and optimization of high- and medium-throughput CAR-T cell manufacturing workflows
• Perform flow cytometry-based experiments for cellular characterization and analysis
• Perform Droplet Digital PCR (ddPCR) assays and analysis of vector copy numbers (VCN) of CAR T cells
• Operate, maintain, and troubleshoot basic automation systems utilized in cell therapy processes
• Identify and resolve technical challenges encountered during laboratory procedures to ensure smooth workflow
• Analyze experimental data using software tools such as GraphPad PRISM, FlowJo, and Microsoft Office Suite
• Maintain precise and comprehensive experimental records in electronic laboratory notebooks (ELNs) to ensure reproducibility and compliance
• Collaborate with cross-functional team members to refine protocols, enhance process efficiency, and achieve project milestones
• Strictly adhere to safety protocols, regulatory standards, and laboratory guidelines while performing experiments

Qualifications:

• Bachelor's degree in Biology, Biotechnology, Biomedical Engineering, or a related field and at least 2 years of laboratory experience (industry experience is preferred).
• Or a Master's Degree in Biology, Biotechnology, Biomedical Engineering or a related field with at least a year of laboratory experience.
• Hands-on experience with Pipetting (single and multi-channel pipettes), aseptic cell culture, cell banking, with a strong preference for experience working with primary immune cells.
• Experience with multicolor Flow Cytometry is required.
• Experience with ddPCR and VCN assays is highly preferred.
• Experience working in BSL2 and BSL2+ labs; familiarity with viral transduction techniques is highly desirable.
• Exposure to automation technologies used in laboratory workflows is preferred.
• Basic proficiency with data analysis tools and software, such as GraphPad PRISM, FlowJo, and Microsoft Office.
• Strong organizational abilities and attention to detail, with a demonstrated ability to maintain clear and accurate records.
• Effective communication and interpersonal skills to succeed in a collaborative team setting.
• Motivated, and ability to learn new techniques, perform multiple tasks simultaneously.
• Authorization to work in the United States indefinitely without restriction or sponsorship.
• Availability to work on-site in Spring House, PA, during standard business hours.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center or contact AskGS to be directed to your accommodation resource.