Associate Scientist – In Vivo Pharmacology Full-time

Associate Scientist – Pharmacology

Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

The Protein Homeostasis Thematic Research Center (TRC) at BMS is a fundamental Oncology research engine delivering oncology and hematology therapeutics to patients. The TRC has a major focus on exploiting BMS' expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable.

The Pharmacology group within the Protein Homeostasis TRC at BMS San Diego provides in vivo pharmacology support to discovery teams focused on developing small molecules and biologics for oncology and immune-oncology. As an integral part of discovery programs, the group supports lead identification through in vivo model screening and mechanism-of-action studies, develops and validates animal disease models, identifies pathway biomarkers, and establishes clinically relevant endpoints to assess efficacy. Collaboration with DMPK, Exploratory Toxicology, and Translational Development is central to our work, and we contribute preclinical data to inform clinical development plans.

Position Summary: We are seeking a motivated Associate Scientist with broad experience in pharmacology and drug discovery for both small and large molecules. The successful candidate will work collaboratively in a multidisciplinary environment, taking responsibility for experiment design, planning, and execution. Key duties include interpreting and presenting in vivo data, conducting sample and endpoint analyses (ELISA, Western blot, Jess, qPCR, IHC), and preparing protocols and reports. The role requires independent work, technical expertise, and contributions to project decisions. Strong communication, self-motivation, innovation, flexibility, and teamwork are essential.

Position Responsibilities: In the role as an Associate Scientist within Pharmacology, the ideal candidate will be responsible for the following:

• Develop disease models for oncology and immune-oncology
• Independently design and execute in vivo efficacy and PK/PD experiments to identify drug candidates
• Analyze and interpret data accurately, reporting findings to supervisors and colleagues
• Troubleshoot routine issues and recommend solutions
• Evaluate endpoints from in vivo studies using Western blots, mesoscale, qPCR, etc.
• Write precise protocols and technical reports
• Present data to multidisciplinary discovery teams
• Collaborate with cross-functional team members

Basic Qualifications:

• Bachelor's Degree
• 2+ years of academic and/or industry experience

Preferred Qualifications:

• Bachelor's Degree and 2+ years of academic and/or industry experience with oncology models
• Experience in mammalian cell culture
• Experience in the development of syngeneic and xenograft cancer models
• Proficient in animal handling, dosing (PO, IP, IV, and SC), tumor cell inoculation, data collection and analysis
• Hands-on experience in small animal surgeries, necropsy and tissue and blood collection
• Hands-on experience in evaluating small molecules in animal models
• Experience with small animal imaging modalities (e.g., Xenogen, ultrasound etc.) is a plus.
• Skilled in Western blots, ELISA, MesoScale, IHC, flow cytometry, RNA/DNA extraction, and PCR
• Proficient in Excel, Word, PowerPoint, FlowJo, GraphPad Prism, and Studylog
• Excellent interpersonal, communication, presentation, collaboration, and organizational skills
• Detail-oriented, focused, and able to deliver high-quality data efficiently

Compensation Overview: San Diego – CA – US: $93,230 – $112,970. The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit careers.bms.com/life-at-bms/. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients' lives through science™ “, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.