Associate Scientist – LNP Process Development Full-time NEW

LNP PD Associate

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

We are seeking a LNP PD Associate to join our team in Boston, MA. Come join the rapidly expanding Eli Lilly Gene Therapy Team! We are responsible for inventing, characterizing, and advancing novel gene therapy reagents for a myriad of clinical applications. Our team works cross-functionally within our organization across multiple disease areas and platforms. Our goal is to deliver on the promise of gene therapy to patients around the world. This role may require up to 10-15% travel for conferences or training and will include the opportunity to mentor and train two junior scientists.

Job Responsibilities

• Implement LNP/TNP formulation studies using bench-scale and pilot-scale equipment (NanoAssemblr, T-mixers, impinging jet mixers)
• Perform downstream processing operations including tangential flow filtration (TFF), buffer exchange, and concentration
• Conduct routine and non-routine characterization of LNP/TNP formulations to assess physical, chemical, and functional properties
• Support the development and optimization of targeted lipid nanoparticle (TNP) formulation processes
• Assist with process characterization studies to understand the impact of process parameters on product quality
• Contribute to scale-up activities by performing experiments at increasing manufacturing scales
• Engage in technology transfer activities

Basic Requirements

• Bachelor's degree in Chemistry, Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences, or related fields with 4+ years of relevant industrial experience
• OR Master's degree with 2+ years of relevant industrial experience
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role.

Additional Preferences

• Recent hands-on experience with lipid nanoparticle or liposome formulation in an industrial or academic research setting
• Proficiency with small-scale LNP formulation using microfluidic mixing systems (e.g., Precision NanoSystems Ignite etc.)
• Experience with mid-scale mixing technologies (T-mixing, impinging jet mixing) is highly desirable
• Hands-on experience with tangential flow filtration (TFF) systems for nanoparticle purification and concentration
• Strong working knowledge of LNP characterization techniques:
• Particle size and polydispersity (DLS)
• Surface charge characterization (zeta potential, ELS)
• Nucleic acid quantification (Ribogreen, absorbance methods)
• Encapsulation efficiency determination
• Solution properties (pH, osmolality, appearance)

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Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $71,250 – $187,000.