Biotransformation Associate Scientist Full-time

Job Title

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

The qualified candidate will join a dynamic lab working on drug candidates in both discovery and development, employing an array of analytical methodologies including HPLC/MS and NMR to quantitatively and qualitatively characterize metabolites from in-vitro and in-vivo drug metabolism studies. The candidate will contribute to developing and optimizing sample preparation workflows and analytical techniques to enhance sensitivity and throughput.

How You Will Achieve It

• Support generation of metabolites for NMR characterization by incubating drug candidates in microsomal and/or hepatocyte systems
• Support analysis of metabolites using analytical HPLC/MS and metabolite isolation using preparative HPLC
• Acquire, process and interpret both 1D and 2D NMR spectra—such as 1H, 13C, COSY, HSQC, HMBC, and NOESY—to determine metabolite structures
• Use 1H and 19F qNMR to measure the concentration of these isolates
• Additionally, the candidate will work with LC-MS/MS data to provide orthogonal structural confirmation of drug metabolites
• Document experimental results, perform critical review of data, and present findings internally and externally
• Interact with peers and leaders in a multidisciplinary team

Qualifications

Must-Have

• B.S. in Biochemistry or Chemistry
• Familiarity with in vitro laboratory techniques
• Coursework and practical lab experience with 1D and 2D NMR spectroscopy
• Solid grasp of organic chemistry and structure-activity relationships
• Research or internship background in pharma, biotech, or CRO
• Experience with qualitative and quantitative NMR software (e.g., MestReNova, TopSpin)
• Strong attention to detail and a commitment to data integrity
• Able to work independently and collaboratively
• Effective scientific communication skills
• Familiarity with troubleshooting of instrumentation
• A commitment to timely delivery of quality work and overcoming obstacles in a fast-paced environment

Nice-to-Have

• Familiarity with LC-MS/HRMS and metabolite profiling
• A basic understanding of drug metabolism pathways (Phase I/II)
• An Undergraduate thesis/capstone involving NMR structural characterization

Work Location Assignment: Hybrid

The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.