Associate Research Scientist Full-time

The Tong Lab in the Department of Biological Sciences at Columbia University invites applications for an Associate Research Scientist. The incumbent should have a full set of experimental skills in structural biology, including protein expression and purification in bacteria and insect cells, protein crystallization, X-ray diffraction data collection and processing, crystal structure determination and refinement, cryo-EM grid preparation and screening, cryo-EM data analysis, cryo-EM model building and refinement, structural analyses and mutagenesis studies.

The responsibilities of this position will include:

·         Cryo-EM studies of Integrator proteins and their complexes with other proteins.

·         Crystallographic studies of proteins involved in RNA processing, alone and in complex with substrates/inhibitors.

·         Detailed analyses of the structures that are obtained, and design mutagenesis experiments to assess the structural observations.

·         Working closely with collaborators, within Columbia and with other institutions, on multi-faceted projects.

·         Preparing reports for grant submissions and drafting manuscripts detailing the results of studies for publication.

·         Mentoring PhD students and colleagues on related projects.

Tagged as: Life Sciences