Doctoral student in image-based single cell profiling and spatial proteomics. Full-time NEW

Doctoral Student In Image-Based Single Cell Profiling And Spatial Proteomics

School of Engineering Sciences in Chemistry, Biotechnology and Health at KTH

Third-cycle subject: Biotechnology

Our lab is seeking a PhD student to apply antibody-based, multiplexed imaging tools to develop spatiotemporal protein maps of human cells and tissues, within the framework of the Human Protein Atlas (HPA). The project focuses on understanding dynamic protein regulation and cell morphology in response to cellular perturbations and activation.

Our research focuses on spatial proteomics and cell biology, bridging bioimaging and proteomics to explore fundamental aspects of human cell biology at the single-cell level. Using an antibody-based approach, we systematically investigate how human proteins are distributed in time and space, how variations in their localization contribute to cell type specificity, and how deviations in protein localization may lead to disease.

In this project, you will develop and apply cutting-edge tools and machine learning techniques to model spatial multi-omics data. The aim is to advance our understanding of protein dynamics at the single-cell level and contribute to a broader understanding of cellular processes. You will also use computational image analysis to study variations in protein spatiotemporal expression patterns in relation to the perturbations and other deterministic factors.

The starting date is open for discussion, though ideally, we would like the successful candidate to start as soon as possible. The placement for this PhD position will be at Science for Life Laboratory in Solna in Stockholm, Sweden, a national centre for molecular biosciences with focus on health and environmental research.

Supervision: Prof. Emma Lundberg and Dr. Diana Mahdessian is proposed to supervise the doctoral student. Decisions are made on admission.

To be admitted to postgraduate education (Chapter 7, 39 § Swedish Higher Education Ordinance), the applicant must have basic eligibility in accordance with either of the following:

• passed a second cycle degree (for example a master's degree), or
• completed course requirements of at least 240 higher education credits, of which at least 60 second-cycle higher education credits, or
• acquired, in some other way within or outside the country, substantially equivalent knowledge
• A suitable background for this position would be a master's degree e.g. in Biomedicine, Biotechnology, Molecular life Sciences or related field.

In addition to the above, there is also a mandatory requirement for English equivalent to English B/6.

In order to succeed as a doctoral student at KTH you need to be goal oriented and persevering in your work. During the selection process, candidates will be assessed upon their ability to:

• independently pursue his or her work
• collaborate with others,
• have a professional approach and
• analyze and work with complex issues.
• Excellent writing and communication skills in English are required. Experience in multiplexed imaging data analysis is a merit

After the qualification requirements, great emphasis will be placed on personal skills.