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Group Leader
Science Team Lead – Cellular Reprogramming Full-time
About us
e184 is a biotechnology research company that supports frontier science and technology in Artificial Reproduction Technologies (ART) and neurotech. Our operating model takes the best from deep-tech VC funds and Focused Research Organizations (FROs). Since our foundation, we’ve backed stellar Paterna Bioscience, supported a neurotech initiative at London Imperial College Neurotech Society, and developed collaborations with numerous scientific organisations worldwide. We are setting up a biotechnology lab focused on developing advanced approaches to cellular fate conversion. Our research integrates cell, developmental, and molecular biology, and high-throughput functional genomics screening to address fundamental questions in reproductive biology. Backed by a private investor, we are building a multidisciplinary team to translate frontier science into clinical and technological applications.
Role overview
We are seeking a Science Team Lead to drive our innovative research program developing novel approaches to cellular fate conversion through transcription factor-mediated reprogramming. This is a leadership position reporting directly to the Chief Scientific Officer (CSO). The successful candidate will guide scientific planning, supervise project execution, contribute to team building, and shape the long-term R&D roadmap. This is a hands-on role: in addition to team leadership and project management, the candidate will be directly involved in designing and conducting experiments at the bench (wet lab), especially in early stages of the program.
What You Will Do
- Lead a focused research team of 4-6 scientists and report directly to the CSO
- Design and personally conduct hands-on research in cellular reprogramming, high-throughput screening, and cell cycle manipulation
- Develop and optimize reporter cell line platforms with integrated fluorescent markers for cellular state transitions
- Establish large-scale screening protocols using CRISPRa and transposon-based transcription factor libraries
- Design and execute pooled genetic screens to identify factor combinations driving targeted cellular conversions
- Supervise validation studies for cellular reprogramming candidates using cytological and molecular approachesImplement high-content imaging systems for phenotype detection and validation
- Work with executive leadership to define research approaches and priorities aligned with company objectives
- Drive scientific output, IP development, and milestone achievement within established timelines
What We Look For
- PhD in Cell Biology, Molecular Biology, or related field
- Minimum 5 years postdoctoral or industry experience in directed cell fate conversion high-throughput genetic screening
- Demonstrated expertise in reporter cell line development and validation
- Technical proficiency in pooled genetic screening methodologies (CRISPRa, library construction, barcode analysis)
- Experience with flow cytometry, FACS, and high-content imaging systems
- Strong background in cell cycle regulation, chromosome imaging, and cytological analysis
- Proven ability to design and execute complex multi-parameter screening experiments
- Experience leading research teams while maintaining significant hands-on involvement
Essential Skills – Epigenetic Editing & Analysis
- Targeted DNA methylation editing (CRISPR-based fusion protein systems) gRNA design and CRISPR construct optimization
- Understanding of genomic imprinting mechanisms
- Long-read methylation analysis (e.g., Oxford Nanopore, PacBio)
- Haplotype phasing and whole-genome methylation profiling
- RNA-seq, ATAC-seq, chromatin dynamics and accessibility analysis
What We Offer
- On-site work on the US Pacific West Coast
- Competitive compensation and benefits package (discussed during an interview process)
- A high-impact leadership role in a mission-driven biotech environment
- Health insurance provided; relocation support negotiable
- Opportunity to shape early-stage scientific vision and company growth
- Collaborative and intellectually stimulating workplace
- Supportive (yet very driven) work environment where your voice and ideas truly matter and quickly translate into decisions and actions.