In Vivo Pharmacology Sr. Associate Scientist Full-time NEW

Senior Associate Scientist – In Vivo Pharmacology

The Oncology Research Unit (ORU) is seeking a hands-on, execution focused Senior Associate Scientist to join the In Vivo Pharmacology group at the Bothell, WA site. This role is primarily responsible for the execution of in vivo experiments supporting preclinical oncology drug discovery programs, including antibody drug conjugates (ADCs).

The Senior Associate Scientist will perform in vivo efficacy, PK/PD, and mechanistic studies, along with in vitro aseptic mammalian tissue culture, generating high quality data that supports project progression. This position is highly lab based and operates within a collaborative research environment where technical rigor, reproducibility, and compliance are critical.

Key Responsibilities

In Vivo Study Execution (Primary Focus)

• Execute in vivo pharmacology studies to assess anti-tumor efficacy, dose response, PK/PD relationships, and mechanism of action.
• Perform routine and advanced in vivo dosing techniques (IV, IP, SC, PO) in tumor bearing mice.
• Conduct tumor measurements, clinical observations, necropsy support, and biological sample collection (blood, plasma, tumors, tissues).
• Utilize a variety of oncology models, including CDX, PDX, syngeneic, GEMM, and humanized mouse models.

Aseptic Technique & Mammalian Tissue Culture

• Perform aseptic mammalian tissue culture to support in vivo studies, including cell expansion, maintenance, and preparation for tumor implantation.
• Generate high-quality cell preparations for in vivo tumor model establishment.
• Apply strict aseptic technique to ensure sterility, reproducibility, and experimental integrity.
• Maintain cell culture documentation, inventory, and quality control records.

Data Handling & Team Communication

• Document and maintain accurate and compliant electronic laboratory notebooks and experimental records in accordance with IACUC regulations and Pfizer standards.
• Compile, organize, and summarize experimental data for internal reports and presentations.
• Communicate results clearly during project and group meetings.
• Support multiple concurrent studies by managing day-to-day experimental execution and timelines.

Qualifications

Required

• BS with 3+ years of relevant experience or MS with 1+ years of relevant experience in in vivo pharmacology, oncology, tumor biology, or a related discipline.
• Demonstrated hands-on experience with murine in vivo tumor models.
• Experience performing in vivo dosing, tumor measurements, necropsy support, and sample collection.
• Strong attention to detail, documentation quality, and experimental reproducibility.

Preferred

• Experience supporting oncology drug discovery programs, particularly ADCs or immuno-oncology agents.
• Proven proficiency in aseptic technique and mammalian tissue culture.
• Familiarity with basic PK/PD concepts.
• Experience working in a high-throughput, multi-project laboratory environment.
• Experience training or mentoring junior research staff on laboratory techniques.

Role Emphasis (Execution-Focused)

• Majority of time spent performing laboratory-based experimental work
• Limited scope beyond study execution and data generation
• Emphasis on technical excellence, consistency, and high-quality data delivery
• Works under direction of senior staff members who provide study objectives and oversight

Physical/Mental Requirements

Requires ability to perform in vivo laboratory work including sitting, standing, lifting (up to ~25 lbs), manual handling of animals and equipment, wearing PPE, and working in regulated animal facility environments. Role requires attention to detail, adherence to safety and animal welfare standards, and flexibility to support study-driven schedules.