Oligonucleotide Synthesis Scientist Full-time

Job Opportunity At GSK

The successful candidate will help to establish pre-clinical capabilities within GSK's new oligo synthesis lab. Areas of focus are SPOS of modalities such as ASOs, siRNA, SSO, and RNA editors screening, high-throughput automation, conjugates, and method development. Your expertise will enable us to solve complex chemical challenges, pushing the boundaries of what's possible in oligonucleotide therapeutics.

This role will provide you the opportunity to lead key activities to progress your career. These responsibilities include some of the following:

• Support pre-clinical oligonucleotide high-throughput and mid-scale synthesis capabilities of ASOs, siRNA, SSO, and RNA editors with routine and novel next generation amidite chemistries.
• Perform hands-on work, maintain high-throughput automation workflows in support of routine and next generation chemistry and oligo method development.
• Maintain standard operating procedures (SOPs) for synthesis, processing, and purification to ensure high-quality, reproducible results.
• Work with the oligo analytical and conjugate chemistry teams to ensure accountability and excellence in oligonucleotide and conjugate synthesis.
• Collaborate with various teams to achieve synthetic project goals.

Why You?

We are looking for professionals with these required skills to achieve our goals:

• PhD with 0+ years, or MS with 2+ or BS with 4+ years' experience in chemistry or chemical biology or related field.
• 2 + years' experience in modern synthetic chemistry methods, particularly nucleosides, nucleotides, and oligonucleotide synthesis, purification, and analysis.
• Familiarity with Mermade 192X with Poseidon software and ÄKTA Oligosynt synthesizers, Cytiva, ÄKTA Avant and Pure purification systems with Unicorn software, and LC/HRMS, UPHLC, LC/MS analytics.
• Proficiency in oligonucleotide synthesis (SPOS), and biological understanding of RNA therapeutics (e.g. ASO, siRNA, SSO, RNA Editors).

Preferred Qualifications:

• MS with 2+ years or above (or PhD +0) in Oligonucleotide synthesis and/or Chemistry and/or related field.
• Team-focused with strong initiative and ability to troubleshoot challenges and implement new solutions.
• Excellent written and verbal communication skills, attention to detail, organizational skills, and the ability to collaborate effectively with a team are required.
• Experience with oligonucleotide conjugation chemistries is desirable but not required.
• Sense of urgency, flexibility, independence and accountability.
• Ability to communicate both verbally and in writing with all levels both inside and outside of organization.
• Maintain a high level of integrity while balancing multiple priorities and responsibilities.
• Must be a committed team player prepared to work in and embrace a team-based culture.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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