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PhD Student
PhD project: Catalytic Synthesis of Bioactive Atropisomers by Aromatic Substitution Full-time
Our group recently developed nucleophilic aromatic substitutions for synthesis of drug-like atropisomers, chiral conformational isomers originating from restricted single bond rotation. In this context, we discovered a fluoride-catalyzed strategy that is remarkably efficient. In this PhD thesis, we will explore this reactivity for synthesis of atropisomers and other bioactive compounds. The primary goal is to advance the field of catalytic organic synthesis. In collaboration, we will evaluate biological activity of the unique molecules synthesized during the project.
University: Faculty of Chemical Technology, UCT Prague; Faculty of Science, Charles University
Group: Paulo Paioti Group, Catalytic Synthesis of Bioactive Molecules
Tutor: Dr. Paulo Paioti
Field of study: Organic chemistry
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