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PhD Student
PhD project: Selection and optimization of modified XNA aptamers Full-time
The topic of the dissertation will be the enzymatic synthesis of hypermodified xeno-nucleic acids and their use in aptamer selection. It will be necessary to develop enzymatic synthesis of modified XNA libraries, selection of binding sequences, reverse transcription into DNA and sequencing. The goal will be the development of stable aptamers binding target molecules (biomarkers, proteins, etc.).
University: Faculty of Chemical Technology, UCT Prague; Faculty of Science, Charles University
Group: Michal Hocek Group / Bioorganic and Medicinal Chemistry of Nucleic Acids
Tutor: Prof. Ing. Michal Hocek, Ph.D. DSc.
Field of study: Organic chemistry
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