PhD Student (f/m/d) | Structural characterisation of α-Synuclein-lipid complexes Full-time

PhD Student Structural Characterisation Of α-Synuclein-Lipid Complexes

The LipAgg project seeks to unravel the structural complexities of amyloid protein-lipid aggregates and investigate their role in pathological aggregation, cellular toxicity, and intercellular spread. Focusing on key human amyloid proteins —amylin (IAPP), amyloid beta (Aβ), and α-synuclein (αS)—linked to type 2 diabetes (T2D), Alzheimer's disease (AD), and Parkinson's disease (PD), respectively, the project builds on recent discoveries made by the consortium. These findings highlight the critical role of free lipids in membrane damage through the formation of stable lipid-amyloidogenic protein complexes, leading to the lipid-chaperone hypothesis.

The selected PhD candidate will participate in the EU-funded HORIZON-MSCA-DN-2024-01 project LipAgg. The LipAgg network brings together partners from five European countries and comprises nine academic institutions and twelve industrial partners. The consortium is committed to delivering an outstanding training programme for fifteen Doctoral Candidates (DCs) aimed at elucidating the role of lipids in the toxicity and propagation of protein aggregation.

The Doctoral candidate key tasks will be to manage and carry out the assigned research project, participate in the LipAgg training and network activities, take PhD courses, write scientific articles and the PhD thesis, participate in national and international congresses and scientific meetings, undertake a research stay at an external research laboratory within the LipAgg network, and disseminate the obtained scientific results.

In particular, the DC enrolled in this position, will determine the structure of such α-Synuclein-lipid complexes by NMR spectroscopy in combination with photo-bleaching for the determination of the stoichiometry of the complexes and molecular dynamics. The protocols to prepare physiologically relevant particles will be established using cellular starting material. The influence of aggregation modulators on the structure of the α-Synuclein-lipid complexes will be part of the project. The Doctoral Candidate will be enrolled at the university of Göttingen in the Gauss program and work at the facilities of the Max Planck institute for Multidisciplinary Sciences under the supervision of Prof. Dr. Christian Griesinger for the structure determination aspects of the work (29 months). The project includes a 6 months secondment at the University of Copenhagen where preparation of near physiological α-Synuclein-lipid complexes will be optimized under the supervision of Prof. Dr. Celine Galvagnion, as well as a 1-month secondment at Bruker, to work with and obtain information about the latest developments at Bruker (Ettlingen, Germany).

The expected start date is 1 September 2026.

The ideal candidate for this position is a highly motivated and talented researcher holding a Master's degree (MSc or equivalent) in chemistry, physics, biochemistry or biophysics. A solid background or keen interest in structure elucidation by NMR and preparation of biologically relevant samples is expected. The ideal candidate should be enthusiastic about tackling new scientific challenges and demonstrate strong motivation, persistence, and a results-oriented mindset. The candidate should be able to work effectively both independently and as part of an interdisciplinary team.

Excellent oral and written communication skills in English are essential. Strong organisational and planning abilities are also required.

This position is subject to the mobility and eligibility rules of the Marie Skłodowska-Curie Actions. In particular, the candidate must not have resided or carried out their main activity (work, studies, etc.) in Germany for more than twelve months during the three years immediately prior to the recruitment date, unless as part of a procedure for obtaining refugee status under the Geneva Convention. At the date of recruitment, the candidate must be a Doctoral Candidate, i.e. in the first five years (full-time equivalent research experience) of their research career and must not have been awarded a doctoral degree.

The successful candidates will receive a gross salary of 4.768,12€ plus 660€ family allowance if eligible per month in accordance with the MSCA regulations for Doctoral Researchers. The net salary depends on local tax regulations. The salary includes a living allowance (4.058,12€), a mobility allowance (710€), and a family allowance (660€ if applicable). The PhD funding is for 36 months.

Required documents:

• CV – including methodological skills
• Motivation letter
• Copy of Master's degree (or proof of expected completion)
• Master's thesis (if available)
• All academic transcripts
• Contact information for at least two references

To get more details please write to cigr@mpinat.mpg.de and celine.galvagnion@sund.ku.dk