Pfizer is seeking a highly motivated postdoctoral fellow with training in structural biology of G protein-coupled receptors (GPCRs) or other membrane proteins to advance next-generation structure-based drug discovery (SBDD) by integrating pharmacology, cryo-electron microscopy (cryo-EM), and artificial intelligence (AI)–enabled experimental strategies to interrogate dynamic and pharmacologically relevant GPCR functional states.
This role is part of an R&D-funded, AI-focused postdoctoral initiative aimed at enabling structural access to GPCR conformations that are currently difficult or impossible to study using conventional approaches. The successful candidate will work at the interface of experimental GPCR pharmacology and high-resolution cryo-EM structural biology and will have a unique opportunity to collaborate closely with a parallel AI/ML/Computer Science–focused postdoctoral fellow, contributing experimental data and domain insight to an iterative, data-driven model-refinement framework that links pharmacology and cryo-EM outcomes with AI-enabled design.
Key responsibilities include:
The postdoctoral fellow is expected to play an active role in shaping the scientific direction of the project and to contribute to the development of scalable experimental strategies that expand Pfizer's GPCR discovery and SBDD capabilities.
Required qualifications:
Preferred qualifications:
Additional information: Relocation support available. Work location assignment: On Premise. Last date to apply: April 30th, 2026. The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
Tagged as: Life Sciences
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