Postdoctoral Researcher in Experimental Systems Neuroscience & Viral Engineering Full-time

Postdoctoral Researcher in Experimental Systems Neuroscience & Viral Engineering

Do you want to contribute to top quality medical research?

Stagkourakis & Nyberg Labs, Karolinska Institutet & SciLifeLab

The Stagkourakis and Nyberg Labs, located in state-of-the-art facilities at the interface of Karolinska Institutet (KI) and SciLifeLab in Stockholm, are recruiting a postdoctoral researcher to work on the development of Fast, Light-And-State-gated, Retro-Orbital AAVs to Tag & Control Neural Ensembles, an interdisciplinary project jointly led by Stefanos Stagkourakis and William Nyberg and supported by the KI research incubator program (KIRI).

The Stagkourakis labs is embedded in the Dept. of Neuroscience at Karolinska Institutet and is part of SciLifeLab, a Swedish national center for large-scale molecular biosciences and cutting-edge infrastructure. Our research focuses on the neural basis of prototypical behaviors, including aggression, defensive states, and parental care, using a combination of advanced behavioral paradigms, in vivo recordings, and circuit manipulations.

The Nyberg Lab, based at the Department of Medicine, Huddinge and SciLifeLab, develops evolved AAV capsids and state-controlled gene-expression technologies for in vivo viral engineering. This project brings the two laboratories together to build a shared experimental platform that neither lab could develop alone.

The postdoc will be primarily based in the Stagkourakis Lab for day-to-day experimental work, but will be fully embedded in both laboratories, with structured co-mentorship from Nyberg and regular integration into both research environments. For more information on the Stagkourakis Lab and the Nyberg Lab, see the links provided.

The Department of Neuroscience at Karolinska Institutet hosts ~20 research groups working on fundamental and disease-related aspects of nervous system function. SciLifeLab is a national research infrastructure providing unique technologies and expertise in molecular biosciences, closely integrated with the KI research community and partner universities.

The position is part of a long-term interdisciplinary collaboration with Dr William Nyberg, Assistant Professor at the Department of Medicine, Huddinge, and SciLifeLab, whose group develops evolved AAV capsids and optically controlled gene-expression systems for in vivo cell engineering. The successful candidate will help consolidate and expand this joint platform.

Candidate's profile

We are looking for a curious, hands-on experimentalist who enjoys working across methods and disciplines. Required qualifications and experience:

• A PhD (or equivalent) in neuroscience, biomedical sciences, bioengineering, or a closely related field, obtained no more than a few years before the start date (according to KI postdoc rules).
• Strong experience in in vivo rodent experiments, with competence in at least one of: Stereotaxic surgery and viral/vector delivery, in vivo imaging (miniscope, 2P), optogenetics/chemogenetics in behaving animals.
• Design and execution of behavioral paradigms in mice.
• Demonstrated scientific productivity, typically through first-author publications or equivalent outputs.
• A high degree of independence, good organizational skills, and strong communication in English (spoken and written).
• Strong social skills and ability to work both independently and to be part of teams – all aspects necessary for this role.

Candidates with demonstrated expertise in one or more of the following are particularly encouraged to apply:

• AAV or lentiviral work (design, preparation, or in vivo use).
• Integration of behavior with imaging/optogenetics in mice.
• Development of custom behavioral tasks and closed-loop experimental designs.
• Proficiency in basic data analysis in Python or MATLAB (more advanced modeling will be supported by collaborators).
• Prior work in collaborative, interdisciplinary projects.

Most importantly, we value enthusiasm for learning new techniques, the ability to troubleshoot complex experiments, and an interest in understanding how survival circuits are organized and controlled.

What do we offer?

We provide a creative and collaborative environment with wide-ranging expertise: A joint supervision structure where you are primarily based in the Stagkourakis Lab (behavior, imaging, systems neuroscience) with co-mentorship from the Nyberg Lab (AAV engineering, optogenetic gene control). Access to:

• Fully equipped behavior rooms and animal facilities (KM-B/KM-F).
• Two-photon microscope with SLM module, Inscopix miniscope, and fiber-optic setups.
• AAV production/purification infrastructure and molecular biology facilities via the Nyberg Lab and SciLifeLab.
• On-the-job training in scientific and technical skills, plus mentoring in writing papers and grant applications, presenting data (talks and posters), supervising students and coordinating collaborative projects.

You will also be part of the broader KI Neuroscience and SciLifeLab communities, with opportunities to attend seminars, workshops, and courses in research leadership, ethics, and data management. As a postdoc in this project, you will be part of KIRI, the Karolinska Institutet Research Incubator, a unique initiative at KI to build a community for interdisciplinary research and breakthrough discoveries. You will have access to two PIs that you can meet and interact with to facilitate the research process and increase the synergetic effects. You will also have the opportunity to meet other KIRI postdocs, present your work at scientific events, and take part in KIRI activities. Read more about KIRI here.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

• Your application should be submitted in English through the Varbi recruitment system and must include:
• CV (max 3–4 pages), including: Publication list, Date of PhD defence (or expected date), Previous positions and academic distinctions.
• Cover letter (1–2 pages) describing your research interests and how they align with the discussed project, your relevant experimental experience, and your motivation for joining the Stagkourakis and Nyberg labs.
• Contact details for at least two references (or reference letters, if available).

Required academic qualifications

To be eligible, you must:

• Hold a PhD degree or a foreign degree deemed equivalent to a PhD in a relevant field.
• Have completed your PhD no more than four years before the start of the position (extensions allowed for parental/sick leave according to KI rules).
• Candidates who have not yet defended may apply; however, all requirements for the doctoral degree must be completed before the start date.

Type of position

This is a full-time postdoctoral position funded by the KIRI-Fellow postdoc project grant for two years, with the possibility of extension depending on performance and available funding. Employment conditions follow the local agreement for postdoctoral researchers at Karolinska Institutet.

Welcome to apply at the latest 2026-03-29.

The application is to be submitted through the Varbi recruitment system.