Postdoctoral Researcher in Frizzled structural biology and receptor pharmacology Full-time

Postdoctoral Researcher in Frizzled Structural Biology and Receptor Pharmacology

Do you want to contribute to top quality medical research?

In the research group “Receptor Biology & Signaling” led by Professor Gunnar Schulte, the focus is on G protein-coupled receptors and in particular class F receptors. The work aims to better understand how Frizzleds are activated, how conformational changes contribute to receptors activation and consequently how downstream signaling is specified. Functional selectivity of class F receptors against different intracellular transducers is analyzed in the hope of exploiting the new knowledge therapeutically.

For more information: https://ki.se/en/fyfa/schulte-lab

Your Mission

The research project aims to understand the underlying molecular details of class F receptor activation for future drug development. The project brings together disciplines such as structural biology (CryoEM), pharmacology, biophysics, molecular biology and oncology. The highly motivated candidate, with a strong background in GPCR structural biology AND pharmacology, is expected to drive the research project, technical development and concept development from idea to publication.

You will participate in the supervision of master's and doctoral students. In addition to lab work, the applicant is expected to take an active, constructive and developing part in lab management and undergraduate teaching.

Your Profile

To be eligible for employment as a postdoctoral researcher, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier.

Requirements for the position:

• In-depth background in structural biology and CryoEM, biochemistry, molecular biology and cell biology with an emphasis on GPCR pharmacology and resolution of small molecule-receptor complexes.
• Solid experience in cell culture (mammalian and insect cells), protein biochemistry, resonance energy transfer (FRET/BRET) techniques, cloning, assay design and assay validation
• Documented (high profile publications) experience in membrane protein purification and CryoEM

Great emphasis will be placed on personal qualities in the selection of the candidate.

What Do We Offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Fixed-term employment for 12 months.

Location: Solna