Postdoctoral Researcher in Molecular Biophysics Full-time

Postdoctoral Researcher in Molecular Biophysics

Uppsala University, Department of Cell and Molecular Biology

Do you want to work in molecular biophysics, supported by skilled and friendly colleagues in an international environment? Would you like an employer that promotes sustainable working conditions and offers secure, beneficial employment terms? You are welcome to apply for a postdoctoral position in molecular biophysics at Uppsala University.

The Department of Cell and Molecular Biology is divided into seven research programs, each focusing on different areas within cell and molecular biology: computational biology and bioinformatics, microbiology and immunology, molecular biology, molecular biophysics, molecular evolution, molecular systems biology, and structural biology. The scientific foundation of our work lies in biology, but our research overlaps with other fields such as medicine, computer science, mathematics, chemistry, engineering, and physics. The department has more than 200 employees, including around 60 PhD students.

The work in Michael Landreh's research group focuses on the development and application of protein engineering and mass spectrometry to understand the structure–function relationships of challenging protein systems, including membrane proteins and amyloids, which play key roles in cancer and neurodegeneration. The laboratory includes facilities for protein production and characterization as well as cutting-edge mass spectrometry. We collaborate with the laboratories of Associate Professor Axel Abelein and Professor Marie Arsenian-Henriksson at Karolinska Institutet, which routinely use advanced live-cell microscopy, cell sorting, and structural analysis to study molecular mechanisms. This enables us to combine structural biology with cellular disease models to study protein function from the molecular to the organismal level.

Duties

The successful candidate will characterize phase-separated protein complexes. Using various molecular biology and biophysical techniques—primarily mass spectrometry and mass photometry, as well as nuclear magnetic resonance spectroscopy and free-electron lasers—we will investigate protein structures and interactions and how they are affected by phase separation. The focus of the postdoctoral project is to continue ongoing work in the group on mass spectrometry methods to study proteins under conditions as close to physiological as possible. The postdoctoral researcher will express and purify proteins, monitor their structure and interactions, and correlate structural changes with biological activity. The project is a collaboration with the groups of Axel Abelein and Marie Arsenian-Henriksson at Karolinska Institutet.

Qualification Requirements

A PhD in medical science or a foreign degree considered equivalent to a PhD in medical science. The degree must be completed by the time employment begins. Priority will be given to applicants who obtained their PhD no more than three years ago. The reference point for the three-year period is the application deadline. If there are special reasons, the degree may have been obtained earlier. Special reasons include leave due to illness, parental leave, union responsibilities, etc. The postdoctoral researcher is expected to have documented experience in protein analysis and membrane biophysics. Demonstrated expertise in biophysics and molecular biology—including protein design and production in bacteria, as well as electron microscopy—is highly important.

Desirable/Additional Qualifications

Documented experience in protein production, mass photometry, free-electron lasers, and nuclear magnetic resonance spectroscopy. Experience with computational analysis such as simulations and machine learning is a plus. Great importance is placed on interpersonal skills, willingness to work in a team, and excellent proficiency in English.

About the Employment

The employment is a temporary position of at least two years, and at most three years, according to central collective agreement. Full time position. Starting date as agreed. Placement: Uppsala

For further information about the position, please contact: Michael Landreh, Professor of Molecular Biophysics, +46 76 292 59 29, michael.landreh@icm.uu.se

Please submit your application by 9 April 2026, UFV-PA 2026/933.