Postdoctoral Researcher in Quantitative Proteomics and Post-translational Modifications Full-time

Postdoctoral Researcher In Quantitative Proteomics And Post-translational Modifications

Applications are invited for a postdoctoral researcher position in quantitative proteomics at the Department of Molecular Biology and Genetics (MBG), Aarhus University, Denmark. The position is available in the Nielsen Lab, which focuses on understanding how post-translational modifications (PTMs) such as ADP-ribosylation networks regulate proteome states and cellular function. The position is initially for two years with the possibility of extension. We are seeking a highly motivated researcher who is excited to play a key role in developing an ambitious research programme and establishing advanced proteomics workflows to study regulatory protein states.

The successful candidate will join a research programme focused on understanding how post-translational modification (PTM) networks regulate protein function and cellular behaviour. The project combines state-of-the-art mass spectrometry-based proteomics, quantitative PTM analysis, and mechanistic cell biology to uncover how regulatory proteome states control fundamental biological processes such as genome maintenance and cellular stress responses. The postdoctoral researcher will contribute to both methodological development and biological discovery, and will play an important role in advancing ongoing research directions while initiating independent projects. Primary responsibilities include:

• Developing and applying advanced MS-based proteomics workflows
• Investigating regulatory PTMs such as ADP-ribosylation and related signalling mechanisms
• Designing and executing independent research projects
• Contributing to the development of experimental workflows and analytical strategies
• Collaborating with national and international partners
• Contributing to high-impact publications and research grant development

The position offers the opportunity to contribute to shaping research directions and developing new experimental approaches within regulatory proteomics. Candidates with a strong background in molecular or cell biology and an interest in applying proteomics approaches are also encouraged to apply.

Applicants should hold a PhD in proteomics, molecular biology, biochemistry, or a related field. We are particularly interested in candidates with experience in one or more of the following areas:

• Mass spectrometry-based proteomics
• Post-translational modification analysis
• Quantitative proteomics workflows
• Cell biology or molecular biology
• ADP-ribosylation or PARP biology

Experience with high-resolution LC-MS systems, PTM enrichment strategies, or large-scale proteomics experiments will be considered an advantage.

The ideal candidate is:

• Scientifically ambitious and highly motivated
• Able to work independently and take ownership of research projects
• Interested in driving projects forward and contributing to an ambitious research environment
• Strong in scientific communication and publication

The position will be based in the Nielsen Lab at the Department of Molecular Biology and Genetics (MBG), Aarhus University. Our research focuses on how post-translational modification networks regulate protein function and cellular behaviour, with particular emphasis on understanding regulatory proteome states. By combining technological innovation in quantitative proteomics with mechanistic cell biology, we aim to uncover how PTM systems such as ADP-ribosylation control fundamental biological processes. The research builds on recent advances in regulatory proteomics and PTM biology and aims to generate mechanistic insights into how complex PTM networks regulate cellular function. MBG provides a highly collaborative and interdisciplinary environment, with strong expertise in RNA biology, structural biology, enzymology, glycobiology and quantitative proteomics.

We offer:

• The opportunity to work in an ambitious and growing research programme within regulatory proteomics
• Access to state-of-the-art mass spectrometry infrastructure
• A highly interdisciplinary and collaborative research environment
• Opportunities for international collaborations and high-impact publications
• Strong support for career development and scientific independence
• A dynamic workplace at one of Europe's leading research universities

Department of Molecular Biology and Genetics, Aarhus University, Universitetsbyen 81, 8000 Aarhus C, Denmark.