Postdoctoral studies in mitochondrial regulation of metabolism (scholarship) Full-time

Postdoctoral Studies In Mitochondrial Regulation Of Metabolism (Scholarship)

The Wredenberg group at Karolinska Institutet is seeking a highly motivated postdoctoral researcher to investigate how mitochondrial function integrates with cellular and organismal metabolism.

Our research focuses on the regulation of mitochondrial function and how its disruption contributes to human disease and ageing. We combine genetic, biochemical, and systems-level approaches alongside in vivo models to define disease mechanisms, with a particular focus on inherited metabolic disorders. A key aim is to understand how mitochondrial pathways influence metabolic adaptation during tissue development and disease.

We employ genetically engineered mouse models, Drosophila, and patient-derived material, combined with molecular biology, biochemistry, and multi-omics approaches. The work is embedded in a collaborative and multidisciplinary environment that links experimental model systems with clinical data.

The group is part of the Division of Molecular Metabolism at Karolinska Institutet, situated in Biomedicum on the Solna campus. The division offers a strong integrative environment that bridges basic research and clinical science, with close collaboration with the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital and access to advanced infrastructure, including national facilities at Science for Life Laboratory (SciLifeLab).

Learn more about the group at: www.wredenberglab.com

The successful candidate will lead and contribute to projects aimed at understanding mitochondrial regulation of metabolism. This includes:

• Designing and executing studies in genetically modified mouse models
• Metabolic phenotyping and analysis of mitochondrial function
• Integrating biochemical and omics-based datasets
• Contributing to study design, supervision of junior researchers, and manuscript preparation

A PhD in molecular biology, metabolism, physiology, or a related field is required. Experience in metabolic research (e.g. mitochondrial biology, intermediary metabolism, or bioenergetics) is also required. Excellent written and spoken English is necessary.

Meriting qualifications include experience with mitochondrial biology, expertise in biochemical assays and/or omics approaches, documented hands-on experience with mouse models (design, breeding, phenotyping), experience working with patient-derived material, and the ability to work independently while contributing to a collaborative environment.

Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent. To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post-doctoral education.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site.

Application must contain the following documents in English or Swedish:

• A complete resumé (max 2 pages) A complete list of publications
• A personal motivation letter explaining your research interest (max 1 page)
• Contact information of at least two references

The application is to be submitted on the Varbi recruitment system.