Postdoctoral studies in Targeted Protein Degradation (scholarship) Full-time

Postdoctoral Studies In Targeted Protein Degradation (Scholarship)

Do you want to contribute to top quality medical research?

Karolinska Institutet offers a uniquely collaborative research environment at the interface of fundamental biology and translational medicine. You will conduct studies at the forefront of ubiquitin biology, replication stress, and cancer drug discovery. The position provides opportunities to engage in international collaborations and contribute to projects with clear therapeutic potential.

Division

The selected candidate will join the Sangfelt Lab at the Department of Cell and Molecular Biology, Biomedicum, Karolinska Institutet. You will be part of a small, dynamic, and closely knit multinational team located in one of Europe's most advanced biomedical research facilities.

Duties

The postdoctoral position centers on ubiquitin‑mediated protein degradation in cancer, with particular emphasis on ubiquitin ligases, replication stress responses, and drug discovery strategies such as molecular glues and targeted protein degradation. Our research integrates molecular and cell biology, biochemistry, genetics, and computational approaches to identify and exploit cancer vulnerabilities.

As a postdoctoral researcher, you will collaborate closely with the group leader and senior scientists to maintain a high level of scientific rigor and professionalism within the team. The ideal candidate has documented experience conducting independent research in the laboratory, taking responsibility for project development within the research area, and demonstrates a strong academic track record, including at least one recent first‑author publication in a high‑impact journal.

You will play a central role in developing and carrying out advanced experimental strategies to harness ubiquitin ligases for targeted protein degradation with relevance to cancer biology and therapy. Your responsibilities will include:

• Designing and conducting biochemical and cell‑based high‑throughput screens
• Structure‑guided optimization and functional characterization of small molecules
• Integrating biophysical, computational, and cell‑based data
• Independent experimental design, data analysis, and interpretation
• Active participation in a multinational research team and international collaborations

Entry Requirements

Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent. To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post-doctoral education.

What Do We Offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site.

Location: Stockholm

Application Process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

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