Principal Downstream Scientist – mRNA purification Full-time

Principal Downstream Scientist – mRNA Purification

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives.

GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.

Are you ready to make a meaningful impact in the development of mRNA-based vaccines? As a Principal Downstream Scientist specializing in mRNA purification, you will play a key role in advancing innovative vaccine platforms. You will design and optimize purification processes, collaborate with cross-functional teams, and contribute to the development of scalable solutions. We value candidates who are driven, collaborative, and eager to bring fresh ideas to the table. This role is based in the United States and offers an exciting opportunity to work at the forefront of vaccine development.

Key Responsibilities:

• Design, execute, and analyze experiments to develop and optimize mRNA purification processes.
• Ensure processes are scalable and phase-appropriate for clinical manufacturing.
• Collaborate with global teams, including analytical R&D, GMP, and process development colleagues.
• Drive innovative solutions to improve purification techniques and meet project milestones.
• Stay current with industry trends and emerging technologies in downstream processing.
• Maintain detailed documentation to ensure data integrity and compliance.

Basic Qualifications:

• Master's or PhD. degree in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related field.
• Five years (Master's) or Three years (PhD.) of industry experience in downstream process development for large biomolecules, including mRNA or pDNA.
• Three or more years of experience with purification techniques such as affinity capture, ion exchange, and hydrophobic interactions.
• Three or more years of experience supporting CMC activities, including process and analytical development.

Preferred Qualifications:

• PhD in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related field.
• Experience with Quality by Design principles and DOE studies for process optimization.
• Knowledge of regulatory guidelines (FDA/ICH/ISPE) for process validation and technology transfer.
• Familiarity with nucleic acid analytical technologies.
• Strong problem-solving skills and ability to work collaboratively in a matrixed environment.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at usrecruitment.adjustments@gsk.com.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.