Principal Research Scientist II, Analytical Development Full-time NEW

Principal Scientist II, Analytical Development

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio.

The Opportunity: We seek a Principal Scientist II, Analytical Development to join an experienced, fast-paced and collaborative team. This position will be primarily responsible for guiding the biophysical analytical strategy and developing novel analytical methods for characterizing AbbVie's mRNA-based targeted lipid nanoparticles (tLNPs) pipeline. This role will manage a small team of scientists focused on biophysical methods for characterizing intact tLNPs and the targeting ligands. Working closely with the technology development and research teams, this position will guide development of novel characterization methods, drive process/product understanding, support expansion of the tLNP platform and pipeline, and support product investigations.

Responsibilities & Duties:

• Lead strategy for and development of novel biophysical methods to characterize tLNP drug product and protein components, including but not limited to LC/CE/MS, DLS, MALLS, Nano flow cytometry, mass photometry, BLI, and plate-based assays
• Design and lead structure-activity relationship and extended characterization studies to improve tLNP function and stability
• Support product characterization for tLNP platform/formulation development and lead candidate selection
• Establish automation/lipid chromohigh throughput (HTP) workflows and in-process analytical methods for routine and non-routine testing of the tLNP pipeline
• Represent functional area in cross-functional pipeline and technology development teams. Effectively communicate complex technical topics to collaborators and management
• Support method transfer and qualifications as needed
• Manage and develop a team of 2-5 scientists
• Draft technical reports and documents as needed

Qualifications:

• Bachelor's Degree in Science related field with 16 years of related work; Master's Degree Science or PharmD with 14 years of related work; PhD in Science or related field with 8 years of related work experience
• Four years of experience managing direct reports and/or a functional team
• Degree in Biochemistry, Chemistry, Bioengineering, Chemical Engineering or related field with proven technical and leadership track record developing analytical characterization methods for nanoparticles (e.g. LNPs, viral vectors, etc) and biologics (e.g. antibodies, mRNA, etc) is required
• Experience developing analytical methods for nanoparticles (e.g. nano flow cytometry, mass photometry, NTA, AUC, etc.) and biologics (e.g. LC, CE, iCIEF, MS, MALLS, BLI, etc) is required
• Experience with method transfer and qualification is preferred
• Strong proficiency authoring and reviewing technical reports
• Familiarity with international regulatory standards and application to phase-appropriate analytical development and strategy is preferred
• Experience designing and executing stability and comparability studies is preferred
• Exceptional communication skills, both written and verbal, with a demonstrated capacity to thrive in collaborative, team-driven environments.

Additional Information:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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Travel: Yes, 10% of the time

Pay Range: $137,500 – 261,000 USD

Where We Work: Role is exclusively performed at a site or office and onsite presence is required. Employees who are site/office-based and can occasionally perform their role virtually work both in the office and remotely, following the policies and regulations in place at their location. US Employees must be in the office on Tuesday, Wednesday, and Thursday with flexibility to work remotely on Mondays and Fridays. Three days in the office is the minimum; some individuals or teams may require more in-office days due to meetings, business/project needs or their role.