Principal Research Scientist – Peptide Analytical Chemistry Full-time

Job Opportunity At AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio.

AbbVie's Synthetic Molecules Analytical Research & Development (Analytical R&D) is a global scientific organization responsible for all analytical CMC activities related to the development of AbbVie's pharmaceutical products. Our scope includes AbbVie's diverse pipeline of innovative synthetic molecules and spans from the selection of Discovery candidate molecules through Early-Stage Clinical Development. We are building a world-class team of scientists and leaders who will drive the advancement of industry-leading analytical capabilities and make meaningful contributions to advance AbbVie's pipeline of innovative medicines. Careers in AbbVie Analytical R&D provide unique opportunities to work with global and cross-functional teams to drive exceptional science and innovative product development strategies. We are looking for diverse candidates with strong scientific background and leadership experience to join the AbbVie's Analytical R&D team and can offer exciting and rewarding career opportunities for these candidates.

For the Principal Research Scientist position, we are seeking a highly motivated, experienced scientist, with expertise in peptide chemistry and associated analytical techniques. This will be supporting early phase development of synthetic peptides, including drug substance and drug product in both preclinical and clinical programs. In addition, the candidate will have the opportunity to drive research initiatives related to peptide design and characterization.

The candidate should have experience in applying regulatory guidelines within an R&D environment with a fit for purpose mind set. He/she should be able to perform research along with directing research by effectively mentoring, guiding and/or supervising scientific personnel. He/she must foster productive collaborations within the global Analytical R&D organization and with R&D cross-functional partners such as Pre-Clinical Safety, Process Chemistry, Process Engineering, Drug Product Development, Molecular Profiling and Drug Delivery, Quality Assurance and CMC-Regulatory.

Key Responsibilities:

• The candidate will participate and/or lead analytical teams associated with drug substance and drug product development and characterization of peptides and other emerging modalities.
• Responsible for fit-for purpose method development, testing procedures, justifying specifications, and implementation of analytical control strategies to help the advancement of drug discovery candidates.
• Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management.
• Mentor and develop scientific staff in troubleshooting strategic and experimental issues and foster a culture of knowledge sharing.
• Leverage prior experience to author and review key regulatory documents, laboratory data, technical memos and reports.
• The position involves multi-disciplinary collaborations across Discovery, Development, Manufacturing, and Regulatory to execute and deliver material and information for clinical trials and regulatory submissions.
• Generate new scientific proposals, related to peptides and other emerging modalities, and lead those efforts.

Minimum Qualifications:

• Bachelors, Masters, or Ph.D. in Analytical Chemistry typically with a minimum of 14 (BS), 12 (MS), or 6 (Ph.D.) years related industry experience.
• Experience with analytical aspects of advancing peptide modalities.
• Strong technical background in analytical chemistry, excellent analytical problem-solving skills. Capable of independently developing and troubleshoot analytical methods.
• Hands on experience with UHPLC analysis and method development along with fundamental understanding and working knowledge of various analytical techniques including Dissolution, MS, GC, and NMR.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs. This job is eligible to participate in our long-term incentive programs.