Principal Scientist Full-time

Principal Scientist, Internal Medicine Research Unit

At Pfizer, our purpose is to deliver breakthroughs that transform patients' lives. Central to this mission is our Research and Development team, dedicated to translating advanced science and innovative technologies into impactful therapies and vaccines. In this role, you will be at the forefront of this effort, ensuring that our daily activities align with our unwavering commitment to quality. Your work will accelerate the delivery of best-in-class medicines to patients globally, fulfilling Pfizer's commitment to making a meaningful difference in healthcare.

The Internal Medicine Research Unit (IMRU) at Pfizer seeks a Principal Scientist to lead discovery efforts focused on anti-inflammatory mechanisms in cardiovascular diseases. The successful candidate will drive target identification and early drug development, leveraging both in vitro and in vivo systems to explore immune and cardiovascular biology. In addition to drug discovery responsibilities, publication in high-impact journals and presentation of research are encouraged. The ideal candidate will bring strong scientific acumen, deep knowledge of immunology and cardiovascular disease, leadership potential, and a collaborative mindset to advance Pfizer's mission in cardiovascular innovation.

Role Responsibilities:

• Lead and execute in vitro and in vivo studies to identify novel therapeutic targets and support drug discovery related to immune dysfunction in cardiovascular diseases
• Apply state-of-the-art cellular, molecular, and animal model techniques to investigate immune mechanisms in cardiovascular pathology
• Collaborate with cross-functional teams and contribute to project strategy, experimental design, data interpretation, and decision-making in a matrixed research environment
• Mentor junior scientists and contribute to a culture of scientific rigor, innovation, and collaboration
• Communicate findings through internal presentations, external conferences, and peer-reviewed publications

Qualifications:

• Basic Qualifications:
• Ph.D. in Immunology, Cardiovascular Biology, or a related field, with postdoctoral research experience
• A minimum of 3 years of relevant industry experience in drug discovery or translational research
• Demonstrated expertise in inflammation and immunology and/or cardiovascular disease biology
• Proficiency in both in vitro (e.g., primary immune or vascular cell assays) and in vivo (e.g., rodent models of atherosclerosis) experimental systems
• Strong analytical and problem-solving capabilities, supported by a track record of impactful scientific contributions
• Excellent written and verbal communication skills, with the ability to effectively present complex scientific concepts
• Proven ability to work collaboratively in multidisciplinary teams
• Preferred Qualifications:
• Experience in leveraging human data sources (e.g., genetics, multi-omics, clinical datasets) to inform and guide therapeutic discovery and development
• Proven leadership and mentoring experience, with a commitment to fostering scientific excellence and team development
• Experience in leading drug discovery projects, with a demonstrated ability to drive scientific strategy and execution

Physical/Mental Requirements:

• Ability to work in a laboratory environment; capacity to lift and move laboratory materials and equipment (up to 25 lbs) as needed

Additional Information:

• Relocation support available
• Work Location Assignment: On Premise
• Last Day to Apply: April 17, 2026
• The annual base salary for this position ranges from $106,000.00 to $176,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program.
• We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com).
• Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility.
• Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.