Principal Scientist, Biophysics Full-time NEW

Principal Scientist, Biophysics

Large Molecule Research drives the discovery and development of innovative biopharmaceutical medicines, advancing a diverse portfolio from early antibody discovery through to molecular engineering and comprehensive biological and physicochemical characterisation.

We are seeking an experienced and motivated Principal Scientist in Biophysics to join our dynamic research team. The successful candidate will play a pivotal role in developing and applying advanced biophysical techniques to support drug discovery and development projects. This is a key hire for those with a proven track record in label-free interaction analysis of protein-protein interactions and deconvolution of complex data in support of mode of action studies, data interpretation, and innovative problem-solving within the biopharmaceutical sector.

In this role you will:

1. Design, plan, and execute experiments using biophysical techniques such as Surface Plasmon Resonance (SPR), Biolayer Interferometry (BLI), size exclusion chromatography (SEC), hydrophobic interaction chromatography (HIC) and differential scanning fluorimetry (DSF) throughout the large molecule discovery process
2. Analyse, interpret, and report complex biophysical data, ensuring high standards of scientific rigour and reproducibility.
3. Lead work to develop and optimise experimental protocols to improve throughput and data quality. Drive data handling strategies, including effective storage, management, and reuse to maximise research impact and compliance with data integrity standards.
4. Collaborate cross-functionally with colleagues in protein engineering, discovery biology, and informatics to deliver integrated project solutions.
5. Present findings to internal teams and external stakeholders; contribute to scientific publications and conferences as appropriate.
6. Mentor junior scientists and contribute to the continuous improvement of laboratory best practices.

Basic Qualifications & Skills:

• PhD (or equivalent experience) in Biophysics, Biochemistry, or a related discipline.
• Significant hands-on demonstratable expertise with SPR or similar technologies (e.g., Biacore, Octet, Carterra), and epitope binning technologies for characterisation of protein-protein and/or protein-antibody interactions.
• Experience working with high-throughput screening and automation platforms in a fast-paced environment in an industry or a relevant research environment.
• Demonstrated ability to analyse, interpret, and visualise complex datasets; proficiency in data management and reuse strategies.
• Strong understanding of molecular interaction theory and its application to drug discovery.
• Demonstrated experience leading matrix teams.

Preferred Qualifications & Skills:

• Project leadership experience.
• Familiarity with AI/ML tools for data analysis.
• Track record of scientific publications or patent filings.

Closing Date for Applications – 19th April 2026 (COB)

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.