Principal Scientist, Biotherapeutics Bioanalyst Bench Scientist Full-time NEW

Principal Scientist

The Biotherapeutics Analytics and Bioanalytics group in Novartis San Diego is seeking a Principal Scientist to join the Biologics Research Center. The primary responsibility of this role is to develop and apply fit-for-purpose analyses of ex vivo samples to enable early-stage project teams to address key scientific questions required for successful project progression. Although the group supports projects deploying a wide variety of biotherapeutic modalities, the initial focus of this position is the targeted delivery of nucleic acid modalities to various cell types of interest.

Key Responsibilities:

• Interact with early-stage discovery teams to understand goals and current challenges faced by the project
• Propose fit-for-purpose analyses best suited to address question at hand
• Implement effective sample analyses pipelines to process and analyze ex vivo samples from numerous projects
• Assign/oversee the work of more junior associates in addition to their own bench responsibilities
• Collate results and explain implications to the research team
• Explore opportunities in both equipment and digital automation to increase sample throughput

Essential Requirements:

• BS or MS degree in an applicable life sciences field, with 10+ years' experience working in a research laboratory in the biotech/pharma industry, or PhD with 2+ years of related industry experience.
• Demonstrated experience supervising junior level associates (or supervision of outsourced work).
• Demonstrated experience developing and running nucleic acid-based analyses from both in vitro and ex vivo samples (mRNA knockdown assessment, stem loop qPCR based measurements, ddPCR etc.).
• Effective collection, documentation, processing and interpretation of data from multiple experiments followed by independent design of the next experiment.

Desirable Requirements:

• Experience with classical protein and biotherapeutic analytical techniques including ligand binding assay development.
• Working understanding of various modes of chromatography and protein mass spectrometry.

Salary Range: $108,500.00 – $201,500.00