Principal Scientist, Cardiovascular Translational Biomarker Full-time

Principal Scientist, Cardiovascular Translational Biomarker

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

The Immunology and Cardiovascular Thematic Research Center (ICV TRC) at BMS is one of the fundamental Research units delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on the cutting-edge science of today. We leverage BMS's internal invention engine that includes industry-leading expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other therapeutic modalities.

Position Summary:

We are seeking a translational scientist with a background in cardiovascular biology to identify and discover novel and existing biomarkers to support the progression of late-discovery programs to early phase clinical trials and beyond. As such, this position will involve a close collaboration with the development organization. The translational scientist may serve as a liaison of discovery to development. The successful candidate will collaborate closely with early discovery team members to drive the progression of programs, which may include assisting the completion of pharmacology studies and guide the selection and analysis of endpoints to support an early translational development plan, including patient segmentation hypotheses. They will be able to apply their knowledge of cardiovascular biology and translational aspects of cardiovascular medicine to establish pharmacodynamic endpoints consistent with mechanism of action, which may involve in vivo, functional-structural analyses and ex vivo or in vitro biochemical or molecular assays, including the development of novel assays. The position may work with human samples or human-relevant systems to test translational hypotheses identified in support of biomarker plan development. This is primarily an on-site, lab-based position but time in lab may be dependent on programmatic needs as discovery programs progress to development, to be determined in collaboration with the manager.

Position Responsibilities:

• Perform studies to define pharmacodynamic biomarkers of response and disease progression, as a member of a discovery team and can investigate and articulate how these biomarkers may translate to the clinic
• Thorough knowledge of experimental design, and a high level of technical laboratory skills (including cell culture of relevant cell lines and primary cells, immunoassays, such as ELISA/MSD, IHC, protein signaling, qPCR technology platforms) together with an ability to interpret results
• Employs technical knowledge and theory to make experimental in-life modifications, when necessary
• Lead studies to completion, including the hands-on analysis of samples internally or directing studies externally through management of CROs.
• Evaluate programs critically and present findings and recommendations to discovery teams and leadership
• Document, critically review, modify experimental approach, if necessary, and present experimental data in a timely manner.
• Collaborate with cross-functional teams by providing timely and actionable study results.
• Provide hands-on training and guidance to develop team members
• Contribute to and author reports, abstracts, and publications.

Experience:

Basic Qualifications:

• Bachelor's Degree
• 8+ years of academic and / or industry experience

Or

• Master's Degree
• 6+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences
• 4+ years of academic and / or industry experience

Preferred Qualifications:

• Ph.D. in Physiology, Pharmacology, Biology, Biochemistry, or a related field with 2+ years of relevant industry experience and 5+ years' experience after completion of terminal degree, including post-doctoral training. PharmD/DVM/MD may be considered with a strong track record of achievement in the basic sciences or drug discovery from hands-on contributions. Alternatively, an M.S. in a related field with 5+ years (after completion of degree) relevant industry experience.
• Strong understanding of cardiovascular physiology and modern cardiovascular methodologies (including those that may serve as pharmacodynamic endpoints) employed pre-clinically and clinically
• Includes a strong understanding of imaging biomarkers used in the clinic (eg ultrasound-echocardiography, MRI, and PET)
• An understanding of the considerations for the use of animals in research, with a focus species-specific use, and can articulate and apply 3Rs principles in designing and initiating experiments
• Hands-on experience handling rodents is necessary
• Expertise culturing and making biochemical and/or functional measurements in iPSC-CM, primary cardiac cells, and/or engineered heart tissues is necessary
• Excellent laboratory skills, prioritizing accurate and reproducible work.
• Skill in managing external collaborators and setting clear timelines and expectations
• Must be self-motivated, detail-oriented, collaborative, and able to work effectively in a multidisciplinary, matrixed team environment.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as “Transforming patients' lives through science™ “, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodations/adjustments prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

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