Principal Scientist, Cell Therapy Vector Engineering Full-time

Principal Scientist, Cell Therapy Vector Engineering

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

We are searching for the best talent for the Principal Scientist, Cell Therapy Vector Engineering to be in Spring House, PA.

Purpose: The Principal Scientist, Vector Engineering position in the Cell Therapy Platform & Discovery group of Therapeutics Discovery offers an exciting opportunity to help develop novel Cell & Gene Therapies for unmet medical needs. We are investigating the use of engineered viral vectors for ex vivo and in vivo gene delivery to T cells to treat cancer. We are seeking a highly motivated scientist to own the design and screening of complex payloads to enable next-generation CAR-T cell products. Do you have industry experience building molecular engineering workflows and the ability to thrive in a cross-functional team? Come join us in our mission to build the next generation of Cell & Gene Therapies for Oncology.

You will be responsible for:

• Leading the design and experimental selection of genetic payloads with complex architectures (e.g. multiple expression cassettes and regulatory elements)
• Building rigorous experimental workflows to establish design rules and methods for delivering complex payloads to primary T cells
• Mentoring junior colleagues to grow their experimental and analytical skills while establishing best practices within the team
• Maintaining detailed records and clearly communicating designs and results to enable efficient data-driven decisions in partnership with stakeholders
• Contributing to a collaborative, creative, and rigorous culture of scientific discovery

Qualifications:

• PhD in Biological Engineering, Synthetic Biology, Immunology, Chemical Engineering, Virology, Biology, or related field with at least 2 years of post-PhD industry experience; or BS/MS in the above fields with 6-8 years of related experience is required
• Industry experience with evidence of scientific project leadership is strongly preferred
• Experience designing and evaluating multicomponent genetic elements in primary cells is strongly preferred
• Required skills: flow cytometry, familiarity with molecular design software (Geneious, Snapgene, Benchling)
• Desired skills include: primary T cell culture, molecular biology assays (such as qPCR or ddPCR, Western blot, ELISA), high-throughput screening, familiarity with DNA/RNA sequencing
• Experience with lentiviral vector payload design is preferred
• Strong critical, scientific, and strategic thinking skills are required
• Strong communication and organizational skills, with the ability to independently manage multiple projects in parallel, are required
• Demonstrated ability to work collaboratively in cross-functional teams is required
• This role may require up to 10% travel.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

Required Skills: Analytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Coaching, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Organizing, Pharmacovigilance, Presentation Design, Process Improvements, Productivity Planning, Scientific Research

Preferred Skills: Analytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Coaching, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Organizing, Pharmacovigilance, Presentation Design, Process Improvements, Productivity Planning, Scientific Research