Principal Scientist (Director), Anatomic Pathologist Full-time

Principal Scientist (Director) – Anatomic Pathology

Translational Molecular Biomarkers is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development at our company's Research Laboratories. Translational Molecular Biomarkers laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets and understand mechanisms of drug action and patient response.

The Molecular Pathology group within the Translational Molecular Biomarkers organization is seeking a highly motivated and experienced Anatomic Pathologist (MD) for the role of Principal Scientist (Director) to join our innovative team. This position will play a crucial role in supporting the development, analytical validation, and testing of histopathology-based assays for clinical implementation and advancing digital pathology within our company's clinical therapeutic pipeline.

The Principal Scientist (Director) will have the following responsibilities:

• Engage in providing thorough histopathological reviews and testing clinical samples, leveraging expertise in disease processes and pathways targeted by our company's therapeutics.
• Collaborate in the development and analytic validation of digital pathology algorithms.
• Interface with scientists and physicians in early and late-stage clinical development to execute histopathology-based biomarker strategies in clinical trials.
• Establish new histopathology-based assays in the laboratory as part of a team.
• Provide subject matter of expert pathologist input to discussions in a highly matrixed environment, collaborating with internal and external stakeholders.

Position Qualifications:

Education Minimum Requirement:

• Doctor of Medicine (MD or MD/PhD) with specialized training in Anatomic Pathology.

Required Experience and Skills:

• Proficient in routine histopathology testing, immunohistochemistry (IHC), cytogenetics (in-situ hybridization) testing procedures, and applicable laboratory testing regulations.
• Experience ensuring compliance of a clinical laboratory with regulatory standards.
• Experience with the development and analytic validation of digital pathology algorithms.
• Excellent oral and written skills with a proven record of scientific contributions to the scientific community.
• Demonstrated ability to lead and manage projects in a fast-paced environment.
• Ability to interact well with diverse groups and maintain strong working relationships with internal and external collaborators.
• Strong understanding of disease processes and pathways relevant to our company's therapeutics.

Preferred Experience and Skills:

• Experience working in the pharmaceutical industry.
• Broad knowledge of the drug development process and translational medicine.
• Experience in clinical biomarker development or managing the implementation of biomarker assays in support of drug development.
• Experience with multiplex tissue-based spatial profiling assays (i.e., multiplex immunofluorescence, multiplex chromogenic immunohistochemistry, imaging mass cytometry).
• Familiarity with image acquisition platforms (i.e., Leica Aperio, Hamamatsu, Pannoramic).
• Proficiency in commercial or open-source image analysis software packages (i.e., Visiopharm, HALO, QuPath).
• Knowledge of using statistical software packages (i.e., Prism, SPSS).
• Understanding of regulated clinical bioanalysis.

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Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. A federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

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The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected US salary range: $250,800.00 – $394,800.00

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance.

Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.

Employee Status: Regular

Relocation: Not Required

VISA Sponsorship: Not Required

Travel Requirements: Not Required

Flexible Work Arrangements: Hybrid

Shift: Not Specified

Valid Driving License: Not Required

Hazardous Material(s): Not Applicable

Required Skills: Not Specified

Preferred Skills: Not Specified

Job Posting End Date: 06/6/2025

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