Principal Scientist, Discovery DMPK Bioanalytical Full-time

Discovery Dmpk Bioanalyst

Are you looking to apply your mass spectrometry skills to solve challenging bioanalytical problems and help drive discovery programs forward, helping patients across the globe.

As a Discovery DMPK bioanalyst, you will be part of a team responsible for the analysis of molecules spanning GSK's portfolio. Using state of the art equipment, we work with compounds at stages from early discovery to development in a fast-paced discovery laboratory environment. In this role you will have opportunities to utilize, challenge, and expand your bioanalytical skill set while planning and building our LC-MS capabilities for biologics.

Responsibilities:

Working within the Discovery DMPK group, you will utilize your lab-bench technical knowledge and apply your experience in LC-MS approaches to support GSK's portfolio deliverables. This role will work across modalities (large/small molecule, oligonucleotides, etc.) but provide key leadership as a subject matter expert in large molecule LC-MS bioanalysis.

In this position, you will have the opportunity to plan, develop, and execute on our objective to provide the large molecule LC-MS analyses required by our evolving portfolio. Working across boundaries, you will help define the trajectory of our LC-MS approaches for biologics, collaborating cross-functionally to understand areas of need and delivering to those goals. By establishing best practices for sample preparation, quantitation strategies, and data analysis you will drive projects forward while building organizational expertise in biopharmaceutical bioanalysis.

Basic Qualifications

We are looking for professionals with these required skills to help us achieve our goals:

• Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related discipline, with 2+ years of relevant postdoctoral/industry experience; or M.S. with 5+ years; or B.S. with 8+ years.
• Expertise in mass spectrometry-based analysis of biopharmaceutics (e.g., antibodies, antibody-drug conjugates) and related components
• Experience in implementing new instrumentation, technology, and workflows to solve challenging analytical problems
• Experience with high resolution mass spectrometry instrumentation and data analysis
• Knowledge of and laboratory experience analyzing DMPK/related assays (in vitro, in vivo, toxicokinetic) using mass spectrometry

Preferred Qualifications

If you have the following characteristics, it would be a plus:

• Proficient in using and troubleshooting Sciex mass spectrometers, including Time-of-Flight instruments
• Experience with the bioanalysis of oligonucleotide therapeutics (siRNA, ASOs, or related modalities)
• Prior involvement in matrix leadership, including leading cross-functional initiatives or guiding scientific strategy across multiple teams.
• Familiarity with regulatory expectations for large molecule bioanalysis.