Principal Scientist, Global Proteomics Full-time

Principal Scientist, Global Proteomics

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

We are searching for the best talent for a Principal Scientist, Global Proteomics to be located in Cambridge, MA.

Purpose: Do you want to use your hard-earned skills and drive to make a difference in the lives of patients? Join the growing Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery to apply groundbreaking approaches to high-scale proteomic analysis! Be part of a motivated team deploying innovative mass spectrometry technologies to tackle challenges in end-to-end drug discovery and development across a leading multiomics organization. We work shoulder-to-shoulder across biology, chemistry, and data science to deliver clear, reproducible proteomic readouts that move medicines forward. With your help, we will drive development of medicines for our patients!

In this role, you will lead global target deconvolution proteomics efforts at scale. You'll build robust, automated workflows and partner with experts across the organization to translate clear, reproducible data into meaningful insights that propel programs forward.

Responsibilities

• Translating scientific goals into high-throughput, automation-ready proteomics workflows with QC and fit-for-purpose SOPs that enable consistency across studies and operators.
• Serving as the proteomics point of contact for assigned programs; aligning on study strategy, timelines, and readouts; communicating results clearly to biology, chemistry, biologics, safety, DMPK, and clinical translation partners.
• Partnering with bioinformatics and IT to ensure FAIR data practices, robust QC pipelines, and timely, decision-ready analyses; harmonizing effort with multi-omics colleagues for coordinated readouts.
• Mentoring and uplifting teammates—sharing mass-spec standard processes, reviewing methods and data, and contributing to a culture of scientific excellence, safety, and continuous improvement.

Qualifications / Requirements

Education:

• A Doctorate degree in Analytical Chemistry, Biochemistry, Chemical Biology, Molecular Biology, Pharmacology or a related field is required.

Experience and Skills:

Required:

• 6+ years of hands-on proteomics mass spectrometry experience, including 3+ years in a drug discovery setting (pharma, biotech, or equivalent applied environment) is required.
• Demonstrated leadership in unbiased, probe-free target deconvolution (e.g., CETSA/TPP, LIP-MS, SPROX, PISA, limited-proteolysis/structural proteomics), from study design through interpretation is required.
• Proven track record industrializing methods: automation-supported sample prep, robust QC, SOPs, and multi-operator reproducibility is required.
• Strong communication and cross-functional collaboration skills; effective planning and the ability to run several projects in a fast-paced environment is required.
• Technical toolkit – Experience with at least one tool from each area is required:
• LC-MS & LC systems: Thermo Orbitrap Exploris/Eclipse/Fusion Lumos/Astral; Bruker timsTOF; Vanquish Neo, Evosep One, Dionex UltiMate.
• Automation Platforms: Hamilton Microlab STAR, Tecan Fluent, AssayMAP Bravo, Beckman Biomek, Dynamic Devices Lynx.
• Data analysis (label-free included): Proteome Discoverer, MaxQuant, DIA-NN, Spectronaut, Skyline.

Preferred:

• Experience scaling platform-level methods and implementing automation-ready protocols is preferred.
• Expertise in PTM-focused proteomics and/or exposure to single-cell or spatial proteomics workflows is preferred.
• Record of scientific innovation (publications, patents) and external visibility (e.g., ASMS, HUPO) is preferred.
• Familiarity with fit-for-purpose quality systems, LIMS, and FAIR data principles is preferred.

The anticipated base pay range for this position is $117,000 to $201,250.

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/performance year. Bonuses are awarded at the Company's discretion on an individual basis.

• Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
• Subject to the terms of their respective plans, employees are eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)).
• Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits:
• Vacation –120 hours per calendar year
• Sick time – 40 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
• Holiday pay, including Floating Holidays –13 days per calendar year
• Work, Personal and Family Time – up to 40 hours per calendar year
• Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
• Condolence Leave – 30 days for an immediate family member: 5 days for an extended family member
• Caregiver Leave – 10 days
• Volunteer Leave – 4 days
• Military Spouse Time-Off – 80 hours

Additional information can be found through the link below.

For additional general information on Company benefits, please go to:

• https://www.careers.jnj.com/employee-benefits

The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.

This job posting is anticipated to close on 03/31/2026. The Company may, however, extend this time-period, in which case the posting will remain available on https://www.careers.jnj.com to accept additional applications.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.

#LI-Onsite

Required Skills:

Preferred Skills:

Big Data Management, Critical Thinking, Data Reporting, Data Savvy, Drug Discovery Development, Molecular Diagnostics, Organizing, Pharmaceutical Microbiology, Problem Solving, Product Knowledge, Project Reporting, Project Schedule, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Standard Scientific Processes and Procedures, Strategic Thinking, Sustainability

The anticipated base pay range for this position is :

$117,000.00 – $201,250.00

Additional Description for Pay Transparency: