Principal Scientist, In Vivo Pharmacology Full-time

Principal Scientist (R5), Quantitative Biosciences, In Vivo Pharmacology

The Discovery Quantitative Biosciences (QB) in vivo Pharmacology team at Boston is looking for an initiative-taking and experienced Principal Scientist with a strong background in Immunology and In Vivo Pharmacology. The successful candidate is expected to drive scientific excellence in the implementation of inflammation/autoimmune model development, in vivo PK/PD and efficacy studies while serving as a key intellectual contributor in the conception and execution of discovery projects. The role will involve significant interaction and collaboration among various functional groups in a highly matrix system and with external partners.

The successful candidate will lead in vivo scientists to:

• Perform experiments using preclinical species to support the discovery and clinical development of novel immunology compounds.
• Manage external studies at CROs and academic collaborators including monitoring study execution and ensuring finalization of study reports within set timelines.
• Manage a group of in vivo scientists, providing guidance, mentorship, accountability, and professional development opportunities.
• Serve as a scientific leader in the Quantitative Biosciences (QB) department at Boston, partnering and aligning with our global, network-wide organizational objectives, and ensuring that we remain at the forefront of drug discovery.
• Represent the QB/Pharmacology functional area at therapeutic area governance forums, program teams, due diligence exercises, and/or cross-functional teams as needed.
• Foster a culture of innovation and continuous improvement within the QB/Pharmacology team, driving the development and adoption of new methodologies and technologies.
• Ensure compliance with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards.

Education:

• PhD in Immunology, Pharmacology, Biology, Biotechnology, Molecular and Cell Biology, Biochemistry, Bioengineering, or related STEM field with 7+ years of industry / biotech experience in immunology drug discovery, or an MS with 10+ years of experience, or a BS with 14+ years of experience.

Required Skills:

• Experience using preclinical models to evaluate the in vivo pharmacology of novel immunology and/or inflammation drugs.
• Proven managerial/supervisory experience with a track record of training, developing talent, and mentoring team members in the field of Immunology/pharmacology and drug discovery.
• Proficiency in complex problem-solving and the ability to influence strategy across organizational boundaries.
• Strong skills in strategic thinking, effective communication, collaboration, balanced risk-taking, and a relentless pursuit of excellence.

Required Skills:

Accountability, Adaptability, Assay Development, Autoimmune Diseases, Biopharmaceutical Industry, Cell Culture Techniques, Clinical Immunology, Communication Strategy Development, Detail-Oriented, Drug Discovery Process, Ethical Compliance, Immunology, Immunotherapy, Inflammatory Diseases, Innovation, In Vivo Models, In Vivo Pharmacology, Leading Project Teams, Mouse Models, Persuasion, Translational Pharmacokinetics and Pharmacodynamics (PKPD)

Preferred Skills:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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The salary range for this role is $176,200.00 – $277,300.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status: Regular

Relocation: Domestic

VISA Sponsorship: Yes

Travel Requirements: 10%

Flexible Work Arrangements: Not Applicable

Shift: Not Indicated

Valid Driving License: No

Hazardous Material(s): Bloodborne pathogens, BSL2, OEB4, OEB5, standard lab reagents

Job Posting End Date: 02/6/2026

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