Principal Scientist, In Vivo Pharmacology, Translational Oncology Full-time

The Opportunity

Join our mission to transform the lives of cancer patients by discovering and developing next-generation therapeutics. We are seeking an accomplished and highly motivated scientific leader to join our In Vivo Pharmacology/Translational Oncology team within the Research Oncology department.

In this role, you will lead a dedicated team of scientists responsible for driving our diverse oncology pipeline, from early discovery to clinical translation. You will provide the scientific and strategic leadership needed to evaluate novel therapeutic concepts, establish clear translational hypotheses, and deliver the critical data packages that advance our most promising drug candidates into the clinic. This is a highly visible and impactful position for a leader who thrives in a collaborative, science-driven environment.

Key Responsibilities

• Lead, mentor, and develop a team of talented scientists and research associates, fostering a culture of scientific excellence, innovation, and collaboration.
• Provide scientific and strategic leadership for the design, execution, and interpretation of in vivo pharmacology studies to assess efficacy, PK/PD relationships, and mechanism of action for novel cancer therapeutics.
• Drive portfolio progression by delivering robust, high-quality “go/no-go” data that directly informs project team decisions and corporate strategy.
• Oversee the generation of IND-enabling data packages for regulatory submissions, contributing your scientific expertise to the authoring of key sections.
• Serve as the in vivo pharmacology expert on cross-functional project teams, working closely with colleagues in Discovery, Antibody Engineering, Safety Assessment, and Clinical Science to build cohesive preclinical data sets.
• Effectively communicate strategy, progress, and data to diverse audiences, including project teams and senior research leadership.

Who You Are

• PhD in Immunology, Oncology, Pharmacology, or a related field with a minimum of 5+ years of relevant industry experience following postdoctoral training.
• Demonstrated experience in managing and mentoring direct reports is required, with a passion for developing scientific talent.
• Extensive hands-on experience designing, executing, and interpreting in vivo studies in oncology, including syngeneic, xenograft, or humanized mouse models.
• Proficiency in integrating efficacy studies with PK/PD and biomarker analyses to establish clear translational hypotheses.
• A proven track record of contributing to IND filings and advancing therapeutic candidates from discovery toward development.
• Deep scientific expertise in either cancer immunotherapy or direct tumor-targeting modalities (e.g., small molecules, antibody-drug conjugates, check-point inhibition).
• Exceptional communication, interpersonal, and collaboration skills, with a proven ability to thrive in a fast-paced, matrix-based team environment.
• The successful candidate will have demonstrated a sustained record of productivity and substantive scientific contributions as determined by consistent high-impact publications and/or external presentations.

Relocation benefits are available for this posting.

The expected salary range for this position based on the primary location of California is $143,200 to $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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