Principal Scientist, In Vivo Tumor Model Oncology Drug Discovery Full-time

Oncology Intracellular Targeted Cancer Therapeutics Principal Scientist

The Oncology Intracellular Targeted Cancer Therapeutics Unit has an opening for an In Vivo Principal Scientist at its Cambridge, MA site. The successful candidate will work together with a highly motivated team to discover and develop novel oncology drugs with a clear genetic relationship to cancer.

The primary responsibility of this position will be to represent in vivo pharmacology in various project teams and lead the in vivo strategy to move the program forward. The candidate should be able to independently execute on a variety of in vivo techniques used to evaluate a compound in mouse tumor models and deliver high quality data. The candidate must be proficient in planning, executing and analyzing data to effectively achieve project goals and timelines.

Responsibilities Include:

• To be the in vivo lead and for early-stage discovery programs and be responsible for generating in vivo proof of concept data for anti-tumor efficacy in genetically relevant tumor models.
• Work with the project team to generate efficacy-PK-PD correlation for the lead compound.
• Share data with the project team and at other internal or external forums.
• Responsible for end-to-end execution of the in vivo tumor model studies including, in life portion, data analysis and recording.
• Works in compliance with GSK's institutional animal welfare guidelines for the use of animals in research.
• Writing study reports for regulatory submissions.

Basic Qualifications:

• Doctorate / PhD in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, or related life sciences field.
• 1+ years of experience with design, conduct, and analyze data from in vivo pharmacology studies.
• Experience in working with vivo tumor models (CDX – Cell line derived, PDX – Patient derived and Syngeneic mouse models).
• Experience managing multiple priorities in a matrix environment.

Preferred Qualifications:

• Knowledge of translationally relevant tumor models in both solid and haem tumor space.
• Demonstrated expertise including PK/PD, efficacy and biomarker studies to inform patient selection strategies, dose and schedule optimization, and identify rationale drug combinations.
• Experience in techniques including- cell culture, compound preparation and formulation, administration to mice (i.v., s.c., p.o.), tumor implantation and measurements.
• Data analytical skills using Prism Graph Pad or other softwares.
• Ability to lead from the bench in problem solving and the development of innovative solutions.
• Excellent communication and presentation skills.
• A proven track record of high productivity and scientific publications in peer reviewed journals.
• Speaks, writes, and listens effectively.
• Excellent record-keeping and organization skills.

The position is available in Cambridge, MA, USA.