Principal Scientist- Molecular/Cellular Biology, Full-time NEW

Principal Scientist, Intracellular Targeted Cancer Therapeutics

At GSK, we aim to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.

The Intracellular Targeted Cancer Therapeutics (ITCT) Biology Unit within the Oncology Research Unit is seeking an experienced Cancer Biologist for a Principal Scientist role that will support a growing portfolio of oncology therapeutics. You will design and execute experiments, analyze data, and collaborate with cross-functional teams to drive impactful therapeutic advancements. We value candidates who are detail-oriented, creative, and passionate about improving patients' lives. Key Responsibilities include:

• Provide basic and translational biology support for target validation, drug discovery, and early clinical development of novel small molecule cancer therapies.
• Work independently to design and execute molecular, biochemical, and cellular assays that support target validation and drug discovery.
• Collaborate with multidisciplinary teams, including chemists, biologists, and data scientists.
• Analyze experimental data, interpret results, and present findings to project teams and the Oncology Research Unit.
• Manage externally resourced projects and ensure timely delivery of high-quality data.

Minimum Qualifications include:

• Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, or related life sciences field with 2+ years of post-doctoral research experience, or an M.S. degree with 3+ years of Pharmaceutical industry experience.
• Experience designing, executing, and analyzing molecular, biochemical, and cellular biology experiments.
• Experience in cancer biology, signaling pathways, or synthetic lethality.

Preferred Qualifications include:

• 2 or more years of drug discovery experience in a biotech or pharmaceutical company.
• Experience in assay development in a drug discovery setting.
• Knowledge of -omic methods (e.g., sequencing, transcriptomics, proteomics) and databases (e.g., DepMap, CCLE, Sanger, etc.).
• Experience working with lab automation including robotic liquid handlers, automated plate readers, etc.
• Attention to detail and proficient reasoning skills in experimental design, data analysis, statistical methods, and interpretation.
• Proven track record of scientific achievement through peer-reviewed publications.
• Ability to work efficiently in a fast-paced, collaborative team environment.
• Strong problem-solving skills and ability to work independently.
• Excellent written and verbal communication skills.

Location: This role is based in the United States and is on-site at either Upper Providence, PA or Cambridge, MA.