Principal Scientist – Oligonucleotide Chemistry Full-time NEW

Principal Scientist

Join Amgen's Mission of Serving Patients

At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

In this vital role you will use your experimental background in oligonucleotide chemistry and biochemistry to design, synthesize, and optimize therapeutic RNA oligonucleotides to directly support the pre-clinical pipeline within Amgen.

• Hands-on laboratory role for the in-house development and optimization of oligonucleotide synthesis and analytical methods
• Conjugation of lipids, carbohydrates and other building blocks to be used for therapeutic oligonucleotide delivery
• Lead internal and external cross-discipline collaborations to advance an RNA therapeutic preclinical pipeline including mentoring junior scientists
• Liaise with external CRO partners to implement and scale synthetic methodologies
• Contribute to overall strategy, including intellectual property planning and competitive landscape assessment

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a chemist with these qualifications.

• PhD and 2 years of relevant industry experience
• Master's degree and 5 years of relevant industry experience
• Bachelor's degree and 7 years of relevant industry experience

• Leadership/mentoring experience
• Ability to effectively communicate within cross-functional teams
• Experience managing and developing relationships with external vendors

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now and make a lasting impact with the Amgen team.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.