Principal Scientist PSTS Transl. PK Full-time

Senior/Principal Scientist – Discovery DMPK Project Lead

In this modality-agnostic position, you will lead the development and execution of translational pharmacokinetics (PK), pharmacodynamics (PD), and investigative toxicology strategies to guide our multidisciplinary discovery teams. You will serve as a scientific leader, providing expertise across all stages of drug discovery—spanning early lead identification to clinical candidate selection—while ensuring alignment with company and regulatory standards.

You will:

• Compose, coordinate, and interpret preclinical ADME/DMPK and pharmacology studies across modalities, collaborating with subject matter experts.
• Develop innovative DMPK and PKPD strategies to support project decision-making and guide candidate optimization and lead selection.
• Stay current with emerging technologies and methodologies in the field of translational sciences, including emerging modalities and bioanalytical techniques.
• Serve as a scientific partner on project teams, providing strategic mentorship and integrating DMPK insights into program development.
• Communicate scientific data effectively to cross-functional teams, management, and stakeholders.
• Contribute to regulatory submissions by preparing and reviewing pharmacokinetics and metabolism sections.

Key qualifications:

• Educational background in biological, chemical, pharmacological sciences, or related fields, with relevant industry experience (≥3-5 years) in preclinical or clinical DMPK.
• Expert knowledge of ADME/DMPK principles for multiple modalities—including small molecules, genetic medicines, and large molecules—coupled with a strong understanding of their relationship to pharmacology, PKPD, and non-clinical safety evaluation.
• Proven track record to develop, initiate, and lead all aspects of DMPK/ADME studies with a solid understanding of regulatory requirements.
• Demonstrated track record of applying innovative DMPK technologies to advance understanding and project decisions.
• Deep understanding of PKPD principles and their application to clinical translation, including PKPD/QSP modeling.
• Excellent written and verbal communication skills, with the ability to work effectively in a global environment, multitask, and adapt to evolving priorities.
• Curious spirit, comfortable challenging the status quo, and passionate about following the science.

What we offer:

• An innovative and collaborative environment where your contributions will directly impact our pipeline and shape the future of therapeutics.
• Opportunities for continuous learning, mentorship, and career growth within a global organization.
• The chance to work at a site that integrates all facets of drug discovery, located near the vibrant city of Antwerp.
• Competitive salary, comprehensive benefits, health & wellness programs, and support for work-life balance.
• An inclusive and diverse team where your ideas and perspectives are valued.