The Ushiki Lab investigates the molecular mechanisms of transcriptional regulation and how noncoding genetic variation alters gene regulation in human disease. Our work integrates functional genomics, human genetics, and in vivo experimental systems to understand enhancer function across regulatory and phenotypic scales. We develop and apply both experimental and computational approaches, including in vivo Massively Parallel Reporter Assays (MPRAs), to define the sequence basis and functional consequences of enhancer activity and to expand MPRA-based approaches to other aspects of transcriptional regulation. Ongoing work in the lab is supported by an NHGRI K99/R00 award and the Preeclampsia Foundation's Peter Joseph Pappas Research Grant. In particular, this position will contribute to projects investigating the relationship between enhancer function and transcriptional elongation, termination, and RNA processing/splicing. Assists with various aspects of the research process in a laboratory setting under the direction of the PI and/or experienced laboratory personnel in order to gain experience to further future career opportunities. Guided activities may include literature review and initial research to identify experimental opportunities, experimental design, execution of experiments and troubleshooting, collection and analysis of data, and/or communication/presentation of results. This role is well-suited for those interested in a gap year(s) where they will be spending time in a research lab acquiring new skills under the direction of the PI and/or experienced laboratory personnel.
Under the direction of the PI or lab members, performs projects, experiments, data collection, and data analysis.
Designs experiments under guidance of PI or senior lab members.
Performs data entry and maintains lab notebook.
Receives mentorship for activities related to career goals and objectives (i.e., PhD or MD programs).
Under supervision, drafts materials for manuscripts, presentations, and/or posters. May present results as directed by PI.
Reviews literature related to relevant research.
Learns lab functions helpful in running a lab (e.g., purchasing, explaining protocols to other lab members).
Assists in developing procedures and guidelines for the lab.
Assists with general lab upkeep, maintenance, and cleaning.
Performs other duties as assigned.
Working Conditions:
Applicant Special Instructions:
The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.
This position is time-limited up to no more than 3 years.
Preferred Qualifications:
Grade: R06-H
Salary Range: $16.92 – $26.44 / Hourly. The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.
For frequently asked questions about the application process, please refer to our External Applicant FAQ.
If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request. All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Personal:
Wellness:
Family:
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University's policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.
Tagged as: Life Sciences
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