Research Assistant in Subcellular Neurodegeneration Part-time

Research Assistant in Subcellular Neurodegeneration

We are seeking a motivated research assistant to join our laboratory investigating subcellular proteomic alterations in cortical neurons derived from patients with frontotemporal dementia (FTD). The successful candidate will work in Dr Ruxandra Dafinca's team in a stimulating environment as part of the Nuffield Department of Clinical Neurosciences and Kavli Institute for Nanoscience Discovery.

Using induced pluripotent stem cell-derived neurons, our group aims to determine regulatory pathways affected by FTD/ALS by implementing the use of subcellular proteomics combined with transcriptomics and super-resolution imaging. This is an exciting opportunity to contribute to the development of novel strategies for high-resolution intracellular neuronal analysis in health and disease, which can be applied across several neurodegenerative disorders. The overarching goals of our work are to mechanistically understand the disease at the molecular level and to identify new therapeutic targets that can inform drug development for FTD.

In this role, you will be responsible for planning and conducting laboratory experiments, analyzing their results and reporting them to the principal investigator. You will work with other team members and external collaborators to investigate subcellular protein interactions using mass-spectrometry, super-resolution microscopy and live cell imaging. You will also contribute to developing complex co-culture systems.

The post is part time at 0.75 FTE, for a fixed term of 12 months in the first instance.