Research Fellow Full-time

Research Fellow

This is an exciting opportunity to work on a project to identify biomarkers and disease mechanisms associated with rare cardiac and metabolic disorders. The applicant will join a British Heart Foundation and BRC at Great Ormond Street Hospital sponsored grant to look at the mechanisms underlying rare cardiac conditions including the arrhythmogenic cardiomyopathies (ACMs). ACMs are a major cause of sudden cardiac death (SCD) affecting 1:2000 individuals worldwide. Yet, risk stratification remains highly challenging, especially in adolescents and young adults, who may not have overt clinical disease. This shortcoming is largely related to ACM being an umbrella term for a broad spectrum of conditions requiring different diagnostic/prognostic frameworks and management approaches. We aim to find new biomarkers, identify disease mechanisms, drug targets and develop new tests for use in the diagnosis, patient stratification and monitoring of trials. The applicant will work in the Translational Mass Spectrometry Group and will be involved in using multiomic techniques to study and understand rare cardiac and metabolic disease. Techniques will include preparing samples and using mass spectrometry for proteomics, metabolomics and lipidomic analyses (Waters UPLC triple quadrupole and QTOF MS instruments).

Applicants are required to have a PhD in biological science and experience in handling and preparing samples. Mass spectrometry experience is a necessity, full proteomics (preferably QTOF) and/or targeted proteomic/metabolite /lipid experience using triple quad mass specs. Experience in bioinformatics (R or python) would be beneficial. Candidates must have the ability to efficiently organise their work and communicate effectively.

As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below:

• 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
• Additional 5 days' annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• Immigration loan
• Relocation scheme for certain posts
• On-Site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insurance

Visit

https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits

to find out more.

As London's Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world's talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL's workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. You can read more about our commitment to Equality, Diversity and Inclusion here:

https://www.ucl.ac.uk/equality-diversity-inclusion/ If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference.