Research Scientist II, Oligonucleotide Chemistry Full-time

Research Scientist II

We are seeking a highly skilled and motivated Research Scientist II to join our dynamic xRNA therapeutics team at our Cambridge site. This role is pivotal in establishing and advancing our oligonucleotide synthesis laboratory. The successful candidate will play a crucial role in synthesizing, purifying, and characterizing therapeutic oligonucleotides, as well as designing novel nucleoside phosphoramidites.

Key Responsibilities:

• Synthesize, purify, and characterize therapeutic oligonucleotides using automated oligonucleotide synthesizers such as Shasta, K&A, or Mermade
• Maintain standard operating procedures (SOPs) for synthesis, processing, and purification of therapeutic oligonucleotides to ensure reproducibility
• Design and synthesize novel nucleoside phosphoramidites for incorporation into therapeutic oligonucleotides

Essential Requirements:

• Bachelor’s degree in a scientific discipline with at least 2 years of experience in organic chemistry, particularly in nucleoside & oligonucleotide synthesis, purification, and characterization. Master’s degree is preferred.
• Familiarity with using automated SPOS (solid phase oligonucleotide synthesis) for therapeutic oligonucleotide synthesis
• Proficiency with purifying, analyzing, and characterizing therapeutic oligonucleotides with LC/HRMS, RP-HPLC, AEX-HPLC, SEC-HPLC, and UV-vis analytics
• Basic understanding of RNA therapeutics and their role in biology
• Be a team player prepared to work in a collaborative, fast-paced environment

Desirable Requirements:

• Prior experience with oligonucleotide bioconjugation is a plus

The salary for this position is expected to range between $73,500-$136,500/year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays, and other leaves.

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion, or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.