Researcher in Immunology Full-time

Researcher in Immunology

Uppsala University, Department of Medical Biochemistry and Microbiology

The Department of Medical Biochemistry and Microbiology (IMBIM) at Uppsala University offers a broad, international environment for research and teaching. IMBIM conducts basic research in biochemistry, cell and molecular biology, tumor biology, comparative genetics, functional genomics, immunology, bacteriology, and virology. The department's research is primarily basic, but its applications have clear connections to and significance for health and disease in both animals and humans. A more detailed description is available at Research – Department of Medical Biochemistry and Microbiology – Uppsala University

The Medical Inflammation Research (MIR) group, led by Professor Rikard Holmdahl at the Department of Medical Biochemistry and Microbiology (IMBIM), Uppsala University. The research aims to improve human health by identifying the regulatory mechanisms underlying autoimmune diseases.

We are seeking a highly motivated researcher lead and coordinate projects focused on in vivo experimental studies of autoimmune diseases, with a focus on rheumatoid arthritis. You will have the opportunity to collaborate with leading experts, gain access to advanced resources, and contribute to groundbreaking discoveries that could shape the future treatment of autoimmune diseases. The position is for 2 years with the possibility of extension for an additional year.

Project Description and Responsibilities

We are interested in uncovering the etiology and regulatory mechanisms underlying the development of autoimmune diseases. Using in vivo models, our goal is to analyze the pathogenic and regulatory mechanisms driving rheumatoid arthritis. In this project, we will investigate the pathological role of human gene variants associated with the evelopment of autoimmune disease. You will have access to unique strains in which parts of the mouse genome have been replaced with corresponding human genes. These mice can develop an immune response similar to that in humans and also have increased susceptibility to human diseases such as rheumatoid arthritis. Using these models, we are working to develop tolerogenic, immunospecific vaccines.

As a researcher, you are expected to take a leading role in the entire research process—from research planning and project administration to data processing, analysis, interpretation, and dissemination of research results. You will work on immunology-focused research, including in vivo experiments, immune assays, and expression analysis. You are also expected to participate in the supervision of master's students and teaching.

Qualification Requirements

• Ph.D. in immunology or a related field
• Applicants must have advanced expertise in animal experimentation (including surgical procedures), flow cytometry, histology, and confocal microscopy.
• Research experience of in vivo handling, breeding, and genotyping; surgical procedures; and laboratory work in cell biology related to arthritis
• Several years of experience in protein biochemistry, particularly recombinant protein expression, purification, and characterization, as well as biostatistical analysis
• Previous experience with the Äkta system, Luminex system, flow cytometry, and antibody-based immunoassays
• Excellent command of English, both spoken and written

We place great emphasis on personal fit and are seeking highly creative and motivated colleagues who enjoy working in a team. We expect applicants to demonstrate good teamwork skills while also being highly independent.

Desirable/Meritorious in Other Respects

A medical degree (MD) is meritorious.

Selection Criteria

When selecting among qualified applicants, particular emphasis will be placed on scientific competence. In this recruitment, the University will primarily consider the candidate who, following a comprehensive assessment of documented qualifications, competence, and skills, is deemed to have the best prerequisites to carry out and develop the relevant duties and contribute to the positive development of the department.

About the Position

The employment is a fixed-term substitute position for up to two years, with a possible opportunity for continued fixed-term employment. The position is full-time. Start date to be agreed upon. Location: Uppsala

For further information regarding the position, please contact: Professor Rikard Holmdahl, rikard.holmdahl@imbim.uu.se

Please submit your application by April 27, 2026. UFV-PA 2026/935